Lymphoid precursors

Koichi Akashi, Tannishtha Reya, Dennise Dalma-Weiszhausz, Irving L. Weissman

Research output: Contribution to journalReview articlepeer-review

65 Citations (Scopus)

Abstract

Lymphopoiesis of mature and diverse populations of T, B and NK (natural killer) cells from multipotent hematopoietic stem cells is an ideal model of tissue generation and regeneration. Identification and isolation of hematolymphoid stem and progenitor cells in several laboratories over the past several years have provided populations that can be studied biologically for lineage commitment and biochemically for receptor function, signal transduction and selective gene expression. These studies may ultimately provide candidate genes involved in lineage commitment, cell death or survival, self-renewal and migratory capacities of progenitors.

Original languageEnglish
Pages (from-to)144-150
Number of pages7
JournalCurrent Opinion in Immunology
Volume12
Issue number2
DOIs
Publication statusPublished - Apr 1 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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