TY - JOUR
T1 - Lysophosphatidylcholine inhibits the expression of prostacyclin stimulating factor in cultured vascular smooth muscle cells
AU - Hashimoto, Toshihiko
AU - Imamura, Minako
AU - Etoh, Takashi
AU - Sekiguchi, Naotaka
AU - Masakado, Mitsunori
AU - Inoguchi, Toyoshi
AU - Nawata, Hajime
AU - Umeda, Fumio
N1 - Funding Information:
This work was supported by a grant-in-aid for Scientific Research (no. 11671127) from the Ministry of Education, Science and Culture, Japan
PY - 2002
Y1 - 2002
N2 - We have cloned a prostacyclin (PGI2) stimulating factor (PSF), which stimulates PGI2 production by vascular endothelial cells. Previous study demonstrated the reduced PSF expression in the coronary arteries from the patients with ischemic heart disease. To clarify the mechanism of reduced PSF expression in atherosclerosis, we examined the effect of lysophosphatidylcholine (lysoPC), a main component of oxidized low density lipoprotein (LDL), on PSF expression in cultured vascular smooth muscle cells. LysoPC reduced PSF expression dose-dependently. Whereas neither phosphatidylcholine nor native LDL affects the PSF expression. Calphostin C, a protein kinase C (PKC) inhibitor, restored the reduction of PSF expression by lysoPC. These results suggest that lysoPC-induced reduction of PSF expression is mediated by PKC activation and is playing a role in the initiation and progression of atherosclerotic lesions.
AB - We have cloned a prostacyclin (PGI2) stimulating factor (PSF), which stimulates PGI2 production by vascular endothelial cells. Previous study demonstrated the reduced PSF expression in the coronary arteries from the patients with ischemic heart disease. To clarify the mechanism of reduced PSF expression in atherosclerosis, we examined the effect of lysophosphatidylcholine (lysoPC), a main component of oxidized low density lipoprotein (LDL), on PSF expression in cultured vascular smooth muscle cells. LysoPC reduced PSF expression dose-dependently. Whereas neither phosphatidylcholine nor native LDL affects the PSF expression. Calphostin C, a protein kinase C (PKC) inhibitor, restored the reduction of PSF expression by lysoPC. These results suggest that lysoPC-induced reduction of PSF expression is mediated by PKC activation and is playing a role in the initiation and progression of atherosclerotic lesions.
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U2 - 10.1016/S1056-8727(01)00211-2
DO - 10.1016/S1056-8727(01)00211-2
M3 - Article
C2 - 11872373
AN - SCOPUS:0036179040
SN - 1056-8727
VL - 16
SP - 81
EP - 86
JO - Journal of Diabetes and its Complications
JF - Journal of Diabetes and its Complications
IS - 1
ER -
