Mac-2 Binding Protein Glycosylation Isomer as a Prognostic Marker for Hepatocellular Carcinoma with Sustained Virological Response

Norifumi Harimoto, Shinji Itoh, Takahiro Yamanaka, Kei Hagiwara, Norihiro Ishii, Mariko Tsukagoshi, Akira Watanabe, Kenichiro Araki, Tomoharu Yoshizumi, Ken Shirabe

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Aim: Mac2-binding protein glycosylation isomer (M2BPGi) is a non-invasive marker for assessing liver fibrosis. This was a retrospective study investigating whether M2BPGi predicts recurrence of hepatocellular carcinoma (HCC) after hepatectomy in patients with HCC who achieved a sustained virological response (SVR). Patients and Methods: We retrospectively reviewed the clinicopathological factors from 60 patients who underwent hepatectomy for HCC after achieving a SVR. We divided all patients into high M2BPGi and low M2BPGi groups and analyzed the clinicopathological and surgical outcomes. Results: High M2BPGi (>1.54, n=23) was significantly associated with lower serum albumin, higher ICGR15, higher Fib-4 index, large blood loss, and worse recurrence-free survival compared to low M2BPGi (≤1.54, n=37). Multivariate analysis identified high M2BPGi and large tumor size as being associated with reduced recurrence-free survival. Multivariate analysis identified lower serum albumin, larger tumor size and higher DCP as associated with reduced overall survival. There was no difference regarding recurrence pattern. Conclusion: Preoperative M2BPGi is a useful biomarker for HCC recurrence after hepatectomy for SVR-HCC.

Original languageEnglish
Pages (from-to)245-251
Number of pages7
JournalAnticancer research
Volume42
Issue number1
DOIs
Publication statusPublished - Jan 2022

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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