Abstract
The requirement of the thymus for the production of la-inducing lymphokine was studied in athymic nude, neonatally thymectomized (NTx), and sham-operated (Sham) miceThe peritoneal macrophages from NTx mice immunized with viable Listeria monocytogenes 14 days previously contained as high a proportion of la-bearing macrophages as those from Sham mice, while those from athymic nude mice contained only a small proportionIntraperitoneal injection of a culture supernatant derived from immune spleen cells of NTx mice induced Iarich exudates in recipient normal mice just as well as did a corresponding supernatant from cells of Sham mice, but that from cells of athymic nude did notThe production of la-inducing lymphokine in culture supernatants of immune spleen cells from both NTx and Sham mice was abolished by pretreatment of cells with anti-Thy-1.2 antibody plus complementThese results suggest that a T cell subset responsible for the production of la-inducing lymphokine requires the presence of the thymus for just a short period in the ontogenic development.
| Original language | English |
|---|---|
| Pages (from-to) | 67-76 |
| Number of pages | 10 |
| Journal | Immunobiology |
| Volume | 171 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Jan 1 1986 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
- Hematology
Cite this
Macrophage Ia Expression in Athymic Nude versus Neonatally Thymectomized Mice. / Koga, T.; Mitsuyama, M.; Watanabe, Y.; Yoshikai, Y.; Nomoto, K.
In: Immunobiology, Vol. 171, No. 1-2, 01.01.1986, p. 67-76.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Macrophage Ia Expression in Athymic Nude versus Neonatally Thymectomized Mice
AU - Koga, T.
AU - Mitsuyama, M.
AU - Watanabe, Y.
AU - Yoshikai, Y.
AU - Nomoto, K.
PY - 1986/1/1
Y1 - 1986/1/1
N2 - The requirement of the thymus for the production of la-inducing lymphokine was studied in athymic nude, neonatally thymectomized (NTx), and sham-operated (Sham) miceThe peritoneal macrophages from NTx mice immunized with viable Listeria monocytogenes 14 days previously contained as high a proportion of la-bearing macrophages as those from Sham mice, while those from athymic nude mice contained only a small proportionIntraperitoneal injection of a culture supernatant derived from immune spleen cells of NTx mice induced Iarich exudates in recipient normal mice just as well as did a corresponding supernatant from cells of Sham mice, but that from cells of athymic nude did notThe production of la-inducing lymphokine in culture supernatants of immune spleen cells from both NTx and Sham mice was abolished by pretreatment of cells with anti-Thy-1.2 antibody plus complementThese results suggest that a T cell subset responsible for the production of la-inducing lymphokine requires the presence of the thymus for just a short period in the ontogenic development.
AB - The requirement of the thymus for the production of la-inducing lymphokine was studied in athymic nude, neonatally thymectomized (NTx), and sham-operated (Sham) miceThe peritoneal macrophages from NTx mice immunized with viable Listeria monocytogenes 14 days previously contained as high a proportion of la-bearing macrophages as those from Sham mice, while those from athymic nude mice contained only a small proportionIntraperitoneal injection of a culture supernatant derived from immune spleen cells of NTx mice induced Iarich exudates in recipient normal mice just as well as did a corresponding supernatant from cells of Sham mice, but that from cells of athymic nude did notThe production of la-inducing lymphokine in culture supernatants of immune spleen cells from both NTx and Sham mice was abolished by pretreatment of cells with anti-Thy-1.2 antibody plus complementThese results suggest that a T cell subset responsible for the production of la-inducing lymphokine requires the presence of the thymus for just a short period in the ontogenic development.
UR - http://www.scopus.com/inward/record.url?scp=0022500680&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022500680&partnerID=8YFLogxK
U2 - 10.1016/S0171-2985(86)80018-3
DO - 10.1016/S0171-2985(86)80018-3
M3 - Article
C2 - 3086214
AN - SCOPUS:0022500680
VL - 171
SP - 67
EP - 76
JO - Immunobiology
JF - Immunobiology
SN - 0171-2985
IS - 1-2
ER -