MAGE-specific cytotoxic T lymphocytes require non-specific CD54 adherence receptors on carcinoma cells.

K. Tahara, N. Sadanaga, H. Nagashima, S. Kitano, M. Mori

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

We investigated several factors that could regulate the susceptibility of carcinoma cells to MAGE-2-specific CTL mediated lysis. Cytofluorometric analysis showed that the cytolysis correlated with the expression of CD54. IFN-gamma treatment induced the TAP-1 and LMP-2 genes, continuously up-regulated the HLA class I expression and increased cytolysis. Although HLA class I were highly induced in MRKnu1 cells, CD54 was not induced and the cytolysis was minimal. Cytotolysis of IFN-gamma-treated MKN-1 cells was completely inhibited by a monoclonal anti-CD54 antibody. These results suggest that HLA-restricted CTL lysis requires non-specific CD54 adherence receptors in addition to specific TCR signals.

Original languageEnglish
Pages (from-to)805-810
Number of pages6
JournalInternational journal of oncology
Volume17
Issue number4
DOIs
Publication statusPublished - Oct 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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