Magnesium deficiency differentially affects the retina and visual cortex of intact rats

Yoshinobu Goto, Akiko Furuta, Shozo Tobimatsu

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

To determine the influence of magnesium (Mg) on the visual system, electroretinograms (ERG) and visual evoked potentials (VEP) were recorded under dark(DA) and light-adapted (LA) conditions in intact rats. Weanling rats were fed either a Mg-deficient (Mg-D) or a control diet for 17 d before the tests, and ERG, VEP and immunohistopathological analyses of retinae and cortices were made. In the Mg-D rats, ear congestion, hair loss and loss of body weight were observed, and serum Mg concentration was ∼25% of that in the control rats (P < 0.01). The amplitudes of the DA a-wave and the second positive peak of the oscillatory potentials (OP2) of the ERG, and the negative component of the VEP (N1) in Mg-D rats were significantly greater than those of control rats. However, the amplitudes of the DA b-wave, LA 2 Hz b-wave, the 20 Hz flicker responses and the implicit times of all response components did not differ between the two groups. The immunohistopathologic results also were not altered in the Mg-D rats. We suggest that the functional abnormalities induced by Mg deficiency may depend not only on the hyperactivity of the N-methyl-D-aspartate (NMDA) receptor, but also on the behavior of the Ca2+ and Mg2+ ions in the intact eye.

Original languageEnglish
Pages (from-to)2378-2381
Number of pages4
JournalJournal of Nutrition
Volume131
Issue number9
Publication statusPublished - Sep 27 2001

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Magnesium Deficiency
Visual Cortex
Retina
Magnesium
Visual Evoked Potentials
Light
Alopecia
N-Methyl-D-Aspartate Receptors
Ear
Body Weight
Ions
Diet
Serum

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Magnesium deficiency differentially affects the retina and visual cortex of intact rats. / Goto, Yoshinobu; Furuta, Akiko; Tobimatsu, Shozo.

In: Journal of Nutrition, Vol. 131, No. 9, 27.09.2001, p. 2378-2381.

Research output: Contribution to journalArticle

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