Magnesium excretion in C. elegans requires the activity of the GTL-2 TRPM channel

Takayuki Teramoto, Laura A. Sternick, Eriko Kage-Nakadai, Shirine Sajjadi, Jakub Siembida, Shohei Mitani, Kouichi Iwasaki, Eric J. Lambie

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Systemic magnesium homeostasis in mammals is primarily governed by the activities of the TRPM6 and TRPM7 cation channels, which mediate both uptake by the intestinal epithelial cells and reabsorption by the distal convoluted tubule cells in the kidney. In the nematode, C. elegans, intestinal magnesium uptake is dependent on the activities of the TRPM channel proteins, GON-2 and GTL-1. In this paper we provide evidence that another member of the TRPM protein family, GTL-2, acts within the C. elegans excretory cell to mediate the excretion of excess magnesium. Thus, the activity of GTL-2 balances the activities of the paralogous TRPM channel proteins, GON-2 and GTL-1.

Original languageEnglish
Article numbere9589
JournalPloS one
Volume5
Issue number3
DOIs
Publication statusPublished - Mar 8 2010

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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    Teramoto, T., Sternick, L. A., Kage-Nakadai, E., Sajjadi, S., Siembida, J., Mitani, S., Iwasaki, K., & Lambie, E. J. (2010). Magnesium excretion in C. elegans requires the activity of the GTL-2 TRPM channel. PloS one, 5(3), [e9589]. https://doi.org/10.1371/journal.pone.0009589