Magnesium excretion in C. elegans requires the activity of the GTL-2 TRPM channel

Takayuki Teramoto, Laura A. Sternick, Eriko Kage-Nakadai, Shirine Sajjadi, Jakub Siembida, Shohei Mitani, Kouichi Iwasaki, Eric J. Lambie

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Systemic magnesium homeostasis in mammals is primarily governed by the activities of the TRPM6 and TRPM7 cation channels, which mediate both uptake by the intestinal epithelial cells and reabsorption by the distal convoluted tubule cells in the kidney. In the nematode, C. elegans, intestinal magnesium uptake is dependent on the activities of the TRPM channel proteins, GON-2 and GTL-1. In this paper we provide evidence that another member of the TRPM protein family, GTL-2, acts within the C. elegans excretory cell to mediate the excretion of excess magnesium. Thus, the activity of GTL-2 balances the activities of the paralogous TRPM channel proteins, GON-2 and GTL-1.

Original languageEnglish
Article numbere9589
JournalPloS one
Volume5
Issue number3
DOIs
Publication statusPublished - Mar 8 2010

Fingerprint

Magnesium
magnesium
excretion
uptake mechanisms
Proteins
Mammals
proteins
kidney cells
Cations
homeostasis
cations
epithelial cells
Homeostasis
Epithelial Cells
Nematoda
mammals
Kidney
cells
Intestinal Reabsorption

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Teramoto, T., Sternick, L. A., Kage-Nakadai, E., Sajjadi, S., Siembida, J., Mitani, S., ... Lambie, E. J. (2010). Magnesium excretion in C. elegans requires the activity of the GTL-2 TRPM channel. PloS one, 5(3), [e9589]. https://doi.org/10.1371/journal.pone.0009589

Magnesium excretion in C. elegans requires the activity of the GTL-2 TRPM channel. / Teramoto, Takayuki; Sternick, Laura A.; Kage-Nakadai, Eriko; Sajjadi, Shirine; Siembida, Jakub; Mitani, Shohei; Iwasaki, Kouichi; Lambie, Eric J.

In: PloS one, Vol. 5, No. 3, e9589, 08.03.2010.

Research output: Contribution to journalArticle

Teramoto, T, Sternick, LA, Kage-Nakadai, E, Sajjadi, S, Siembida, J, Mitani, S, Iwasaki, K & Lambie, EJ 2010, 'Magnesium excretion in C. elegans requires the activity of the GTL-2 TRPM channel', PloS one, vol. 5, no. 3, e9589. https://doi.org/10.1371/journal.pone.0009589
Teramoto T, Sternick LA, Kage-Nakadai E, Sajjadi S, Siembida J, Mitani S et al. Magnesium excretion in C. elegans requires the activity of the GTL-2 TRPM channel. PloS one. 2010 Mar 8;5(3). e9589. https://doi.org/10.1371/journal.pone.0009589
Teramoto, Takayuki ; Sternick, Laura A. ; Kage-Nakadai, Eriko ; Sajjadi, Shirine ; Siembida, Jakub ; Mitani, Shohei ; Iwasaki, Kouichi ; Lambie, Eric J. / Magnesium excretion in C. elegans requires the activity of the GTL-2 TRPM channel. In: PloS one. 2010 ; Vol. 5, No. 3.
@article{204701f50f5a4b6bb91b10e84e2327b3,
title = "Magnesium excretion in C. elegans requires the activity of the GTL-2 TRPM channel",
abstract = "Systemic magnesium homeostasis in mammals is primarily governed by the activities of the TRPM6 and TRPM7 cation channels, which mediate both uptake by the intestinal epithelial cells and reabsorption by the distal convoluted tubule cells in the kidney. In the nematode, C. elegans, intestinal magnesium uptake is dependent on the activities of the TRPM channel proteins, GON-2 and GTL-1. In this paper we provide evidence that another member of the TRPM protein family, GTL-2, acts within the C. elegans excretory cell to mediate the excretion of excess magnesium. Thus, the activity of GTL-2 balances the activities of the paralogous TRPM channel proteins, GON-2 and GTL-1.",
author = "Takayuki Teramoto and Sternick, {Laura A.} and Eriko Kage-Nakadai and Shirine Sajjadi and Jakub Siembida and Shohei Mitani and Kouichi Iwasaki and Lambie, {Eric J.}",
year = "2010",
month = "3",
day = "8",
doi = "10.1371/journal.pone.0009589",
language = "English",
volume = "5",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "3",

}

TY - JOUR

T1 - Magnesium excretion in C. elegans requires the activity of the GTL-2 TRPM channel

AU - Teramoto, Takayuki

AU - Sternick, Laura A.

AU - Kage-Nakadai, Eriko

AU - Sajjadi, Shirine

AU - Siembida, Jakub

AU - Mitani, Shohei

AU - Iwasaki, Kouichi

AU - Lambie, Eric J.

PY - 2010/3/8

Y1 - 2010/3/8

N2 - Systemic magnesium homeostasis in mammals is primarily governed by the activities of the TRPM6 and TRPM7 cation channels, which mediate both uptake by the intestinal epithelial cells and reabsorption by the distal convoluted tubule cells in the kidney. In the nematode, C. elegans, intestinal magnesium uptake is dependent on the activities of the TRPM channel proteins, GON-2 and GTL-1. In this paper we provide evidence that another member of the TRPM protein family, GTL-2, acts within the C. elegans excretory cell to mediate the excretion of excess magnesium. Thus, the activity of GTL-2 balances the activities of the paralogous TRPM channel proteins, GON-2 and GTL-1.

AB - Systemic magnesium homeostasis in mammals is primarily governed by the activities of the TRPM6 and TRPM7 cation channels, which mediate both uptake by the intestinal epithelial cells and reabsorption by the distal convoluted tubule cells in the kidney. In the nematode, C. elegans, intestinal magnesium uptake is dependent on the activities of the TRPM channel proteins, GON-2 and GTL-1. In this paper we provide evidence that another member of the TRPM protein family, GTL-2, acts within the C. elegans excretory cell to mediate the excretion of excess magnesium. Thus, the activity of GTL-2 balances the activities of the paralogous TRPM channel proteins, GON-2 and GTL-1.

UR - http://www.scopus.com/inward/record.url?scp=77949733290&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77949733290&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0009589

DO - 10.1371/journal.pone.0009589

M3 - Article

C2 - 20221407

AN - SCOPUS:77949733290

VL - 5

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 3

M1 - e9589

ER -