Magnetic Field Stimuli-Sensitive Drug Release Using a Magnetic Thermal Seed Coated with Thermal-Responsive Molecularly Imprinted Polymer

Takuya Kubo, Kaname Tachibana, Toyohiro Naito, Sadaatsu Mukai, Kazunari Akiyoshi, Jeyadevan Balachandran, Koji Otsuka

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

A new stimulus-responsive drug delivery system using Fe 3 O 4 nanoparticles coated with molecularly imprinted polymer (MIP) is reported. Magnetic thermal seeds (MTS) with their size controlled between 10 and 20 nm that could generate heat under an alternate current (AC) magnetic field were modified with a thermal-responsive MIP by grafting polymerization for effective release of an anticancer drug, methotrexate (MTX). The MIP-coated MTS showed the superparamagnetic property as well as the selective adsorption ability toward MTX, and 80% of MXT adsorbed on the MIP-coated MTS was stimulus released at 60 °C by cleaving hydrogen bonding in the recognition sites. Finally, the MTX release from the MTX-loaded MIP-coated MTS under an AC magnetic field within 10 min was successfully demonstrated.

Original languageEnglish
Pages (from-to)759-767
Number of pages9
JournalACS Biomaterials Science and Engineering
Volume5
Issue number2
DOIs
Publication statusPublished - Feb 11 2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

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