Magnetic nanoparticle imaging using cooled pickup coil and harmonic signal detection

Keiji Enpuku, Takafumi Morishige, Takuro Mihaya, Takashi Miyazai, Masaaki Matsuo, Seki Haku, Takashi Yoshida

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We developed a highly sensitive measurement system using a Cu pickup coil cooled at 77 K for magnetic nanoparticle imaging. The magnetic field noise of the system was as low as 90 fT/Hz1/2 at the resonant frequency of 3 kHz when the pickup coil was connected to a resonant capacitor. We also characterized the magnetic properties of the nanoparticles for use in magnetic nanoparticle imaging. We demonstrated the detection of nanoparticles using the third-harmonic signal generated by the nonlinear magnetization of nanoparticles. An excitation field having a frequency of 1 kHz and amplitude of 1.6mT was applied to the magnetic particles, and the third harmonic signal at 3 kHz was detected. By separating the signal frequency from that of the excitation field, we could avoid the interference of the excitation field and were able to obtain a clear contour map of the signal field. We could detect 100 μg of magnetic nanoparticles located as far as 100mm under the pickup coil.

Original languageEnglish
Article number087001
JournalJapanese Journal of Applied Physics
Volume52
Issue number8
DOIs
Publication statusPublished - Aug 1 2013

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signal detection
Pickups
Signal detection
coils
Nanoparticles
harmonics
Imaging techniques
nanoparticles
sensors
excitation
resonant frequencies
Natural frequencies
Magnetization
Magnetic properties
capacitors
Capacitors
Magnetic fields
magnetic properties
interference
magnetization

All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Magnetic nanoparticle imaging using cooled pickup coil and harmonic signal detection. / Enpuku, Keiji; Morishige, Takafumi; Mihaya, Takuro; Miyazai, Takashi; Matsuo, Masaaki; Haku, Seki; Yoshida, Takashi.

In: Japanese Journal of Applied Physics, Vol. 52, No. 8, 087001, 01.08.2013.

Research output: Contribution to journalArticle

Enpuku, Keiji ; Morishige, Takafumi ; Mihaya, Takuro ; Miyazai, Takashi ; Matsuo, Masaaki ; Haku, Seki ; Yoshida, Takashi. / Magnetic nanoparticle imaging using cooled pickup coil and harmonic signal detection. In: Japanese Journal of Applied Physics. 2013 ; Vol. 52, No. 8.
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