Magnetically driven micro-movable electrode for cell coupling

Y. Yamanishi, T. Kawahara, T. Iyanagi, M. Hagiwara, Fumihito Arai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We developed a novel method of cell coupling on a chip by using magnetically driven microtool (MMT). It is made of nickel and is used as an electrode as well as a cell pusher. The novelty of this device is the electrode itself whose tip part is supported by a spring and is positioned by external magnetic field. We propose a new cell coupling chip which provides larger coupling force of cells by using a physical motion of MMT. The operation of the microelectrode showed that the oocyte is deformed and the donor cell is successfully coupled physically with the oocyte. The contact area between the cells was increased, and which is good for consequent fusion process. The FEM analysis on the electric field density also showed that a high concentration between the membrane of oocyte and donor cell. The proposed method is suited for cell fusion on a chip, and will contribute to high throughput cell manipulation.

Original languageEnglish
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages905-907
Number of pages3
Publication statusPublished - Dec 1 2010
Externally publishedYes
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: Oct 3 2010Oct 7 2010

Publication series

Name14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume2

Other

Other14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
CountryNetherlands
CityGroningen
Period10/3/1010/7/10

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

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  • Cite this

    Yamanishi, Y., Kawahara, T., Iyanagi, T., Hagiwara, M., & Arai, F. (2010). Magnetically driven micro-movable electrode for cell coupling. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (pp. 905-907). (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010; Vol. 2).