Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche

Fumio Arai, Toshio Suda

Research output: Chapter in Book/Report/Conference proceedingConference contribution

181 Citations (Scopus)

Abstract

Hematopoietic stem cells (HSCs) are responsible for blood cell production throughout an individual's lifetime. Interaction of HSCs with their specific microenvironments, known as stem cell niches, is critical for maintaining stem cell properties, including self-renewal capacity and the ability to differentiate into multiple lineages. During postnatal life, the bone marrow (BM) supports both self-renewal and differentiation of HSCs in specialized microenvironmental niches. In the adult BM, HSCs are located in the trabecular endosteum (osteoblastic niche) or sinusoidal perivascular (vascular niche) areas. Here we show that osteoblastic cells (OBs) are a critical component for sustaining slow-cycling or quiescent HSCs. Interaction of HSCs with OBs through signaling and cell adhesion molecules maintains the balance in HSCs between cell division/proliferation and quiescence. In particular, the quiescent state is thought to be an essential mechanism to protect HSCs from stress and to sustain long-term hematopoiesis.

Original languageEnglish
Title of host publicationHematopoietic Stem Cells VI
PublisherBlackwell Publishing Inc.
Pages41-53
Number of pages13
ISBN (Print)1573316768, 9781573316767
DOIs
Publication statusPublished - Jun 2007
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
Volume1106
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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