Malignant hepatic tumor occurring 10 yrs after a histocompatible sibling donor bone marrow transplantation for severe aplastic anemia

Masataka Ishimura, Shouichi Ohga, Yoshihisa Nagatoshi, Jun Okamura, Tatsuro Tajiri, Kenichi Kohashi, Yoshinao Oda, Hidetoshi Takada, Toshiro Hara

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A 13-yr-old boy developed post-transplant liver tumor. At three yrs of age, this patient underwent a histocompatible sibling donor BMT for severe aplastic anemia, after a conditioning with antithymocyte globulin and cyclophosphamide. He became a HBV carrier after BMT. Stable mixed chimerism and mild thrombocytopenia, but no active hepatitis continued. At age 13, abdominal pain was a sign of massive tumor. Extremely high levels of α-fetoprotein indicated the clinical diagnosis of hepatoblastoma that might be the first report as post-BMT malignancy. The necropsy specimens revealed that the tumor was recipient cell-origin and showed the histopathological features of both hepatoblastoma and hepatocellular carcinoma. Prolonged mixed chimerism and hepatitis virus infection might induce a rare oncogenesis after non-irradiated conditioning.

Original languageEnglish
Pages (from-to)945-949
Number of pages5
JournalPediatric Transplantation
Volume11
Issue number8
DOIs
Publication statusPublished - Dec 1 2007

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Aplastic Anemia
Bone Marrow Transplantation
Siblings
Tissue Donors
Hepatoblastoma
Chimerism
Liver
Neoplasms
Fetal Proteins
Hepatitis Viruses
Antilymphocyte Serum
Virus Diseases
Thrombocytopenia
Cyclophosphamide
Abdominal Pain
Hepatitis
Hepatocellular Carcinoma
Carcinogenesis
Transplants
Conditioning (Psychology)

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

Cite this

Malignant hepatic tumor occurring 10 yrs after a histocompatible sibling donor bone marrow transplantation for severe aplastic anemia. / Ishimura, Masataka; Ohga, Shouichi; Nagatoshi, Yoshihisa; Okamura, Jun; Tajiri, Tatsuro; Kohashi, Kenichi; Oda, Yoshinao; Takada, Hidetoshi; Hara, Toshiro.

In: Pediatric Transplantation, Vol. 11, No. 8, 01.12.2007, p. 945-949.

Research output: Contribution to journalArticle

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AU - Okamura, Jun

AU - Tajiri, Tatsuro

AU - Kohashi, Kenichi

AU - Oda, Yoshinao

AU - Takada, Hidetoshi

AU - Hara, Toshiro

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