Abstract
A 13-yr-old boy developed post-transplant liver tumor. At three yrs of age, this patient underwent a histocompatible sibling donor BMT for severe aplastic anemia, after a conditioning with antithymocyte globulin and cyclophosphamide. He became a HBV carrier after BMT. Stable mixed chimerism and mild thrombocytopenia, but no active hepatitis continued. At age 13, abdominal pain was a sign of massive tumor. Extremely high levels of α-fetoprotein indicated the clinical diagnosis of hepatoblastoma that might be the first report as post-BMT malignancy. The necropsy specimens revealed that the tumor was recipient cell-origin and showed the histopathological features of both hepatoblastoma and hepatocellular carcinoma. Prolonged mixed chimerism and hepatitis virus infection might induce a rare oncogenesis after non-irradiated conditioning.
| Original language | English |
|---|---|
| Pages (from-to) | 945-949 |
| Number of pages | 5 |
| Journal | Pediatric Transplantation |
| Volume | 11 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Dec 1 2007 |
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All Science Journal Classification (ASJC) codes
- Pediatrics, Perinatology, and Child Health
- Transplantation
Cite this
Malignant hepatic tumor occurring 10 yrs after a histocompatible sibling donor bone marrow transplantation for severe aplastic anemia. / Ishimura, Masataka; Ohga, Shouichi; Nagatoshi, Yoshihisa; Okamura, Jun; Tajiri, Tatsuro; Kohashi, Kenichi; Oda, Yoshinao; Takada, Hidetoshi; Hara, Toshiro.
In: Pediatric Transplantation, Vol. 11, No. 8, 01.12.2007, p. 945-949.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Malignant hepatic tumor occurring 10 yrs after a histocompatible sibling donor bone marrow transplantation for severe aplastic anemia
AU - Ishimura, Masataka
AU - Ohga, Shouichi
AU - Nagatoshi, Yoshihisa
AU - Okamura, Jun
AU - Tajiri, Tatsuro
AU - Kohashi, Kenichi
AU - Oda, Yoshinao
AU - Takada, Hidetoshi
AU - Hara, Toshiro
PY - 2007/12/1
Y1 - 2007/12/1
N2 - A 13-yr-old boy developed post-transplant liver tumor. At three yrs of age, this patient underwent a histocompatible sibling donor BMT for severe aplastic anemia, after a conditioning with antithymocyte globulin and cyclophosphamide. He became a HBV carrier after BMT. Stable mixed chimerism and mild thrombocytopenia, but no active hepatitis continued. At age 13, abdominal pain was a sign of massive tumor. Extremely high levels of α-fetoprotein indicated the clinical diagnosis of hepatoblastoma that might be the first report as post-BMT malignancy. The necropsy specimens revealed that the tumor was recipient cell-origin and showed the histopathological features of both hepatoblastoma and hepatocellular carcinoma. Prolonged mixed chimerism and hepatitis virus infection might induce a rare oncogenesis after non-irradiated conditioning.
AB - A 13-yr-old boy developed post-transplant liver tumor. At three yrs of age, this patient underwent a histocompatible sibling donor BMT for severe aplastic anemia, after a conditioning with antithymocyte globulin and cyclophosphamide. He became a HBV carrier after BMT. Stable mixed chimerism and mild thrombocytopenia, but no active hepatitis continued. At age 13, abdominal pain was a sign of massive tumor. Extremely high levels of α-fetoprotein indicated the clinical diagnosis of hepatoblastoma that might be the first report as post-BMT malignancy. The necropsy specimens revealed that the tumor was recipient cell-origin and showed the histopathological features of both hepatoblastoma and hepatocellular carcinoma. Prolonged mixed chimerism and hepatitis virus infection might induce a rare oncogenesis after non-irradiated conditioning.
UR - http://www.scopus.com/inward/record.url?scp=35748981492&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35748981492&partnerID=8YFLogxK
U2 - 10.1111/j.1399-3046.2007.00802.x
DO - 10.1111/j.1399-3046.2007.00802.x
M3 - Article
C2 - 17976134
AN - SCOPUS:35748981492
VL - 11
SP - 945
EP - 949
JO - Pediatric Transplantation
JF - Pediatric Transplantation
SN - 1397-3142
IS - 8
ER -