Malignant lymphoma with c-myc gene rearrangement in a patient receiving long-term treatment for multiple myeloma

H. Ohnishi, T. Kamimura, H. Gondo, T. Okamura, Y. Niho, T. Yao

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We encountered a 65-year-old woman with diffuse large B-cell lymphoma showing t(8;14)(q24;q32) and c-myc gene rearrangement that developed following 12 years of melphalan-based chemotherapy for multiple myeloma. Short-term remission was obtained by CHOP chemotherapy. However, shortly thereafter the patient died of an aggressive progression of lymphoma. It was suspected that the lymphoma was a secondary malignancy related to the treatment with cytotoxic agents and radiation for prolonged multiple myeloma. The chromosomal abnormality t(8;14)(q24;q32) is rare in secondary malignancies. Overexpression of c-myc by gene rearrangement may be associated with clinical courses manifested by the rapid progression of lymphoma.

Original languageEnglish
Pages (from-to)1265-1270
Number of pages6
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume40
Issue number12
Publication statusPublished - Dec 1999

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Fingerprint Dive into the research topics of 'Malignant lymphoma with c-myc gene rearrangement in a patient receiving long-term treatment for multiple myeloma'. Together they form a unique fingerprint.

  • Cite this