Malignant melanoma with a rhabdoid phenotype exhibiting numerous solid tumor masses: A case report

Tomoki Nakamura, Akihiko Matsumine, Hiroaki Kato, Katsuyuki Kusuzaki, Keisuke Nishimura, Tetsuya Murata, Taizo Shiraishi, Yoshinao Oda, Masazumi Tsuneyoshi, Atsumasa Uchida

Research output: Contribution to journalArticle

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Abstract

We present a case of malignant melanoma with a rhabdoid phenotype in a 44-year-old female with a quite unique and aggressive clinical course. Rhabdoid features are defined by characteristics such as sheets or solid trabeculae of neoplastic cells with large, vesicular, round to bean-shaped nuclei, prominent centrally located nucleoli, and abundant eccentric cytoplasm. Although various histological differential diagnoses were cited for the present case that showed 'rhabdoid features', most of them were excluded on the basis of the clinical history, tumor location, clinical behavior, and a broad panel of immunohistochemical stains. In the present case, the immunohistochemical findings were positive for vimentin, S-100 protein, melan-A, and EMA, but negative for HMB45, cytokeratin, CD34 and desmin. In addition, the positive expression of BAF47 was also recognized. These findings lead to the conclusion that this quite unique aggressive soft tissue tumor should therefore be diagnosed as malignant melanoma with a rhabdoid phenotype.

Original languageEnglish
Pages (from-to)887-891
Number of pages5
JournalOncology reports
Volume21
Issue number4
DOIs
Publication statusPublished - Jun 29 2009

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Melanoma
MART-1 Antigen
Phenotype
Desmin
S100 Proteins
Vimentin
Keratins
Neoplasms
Cytoplasm
Differential Diagnosis
Coloring Agents

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Nakamura, T., Matsumine, A., Kato, H., Kusuzaki, K., Nishimura, K., Murata, T., ... Uchida, A. (2009). Malignant melanoma with a rhabdoid phenotype exhibiting numerous solid tumor masses: A case report. Oncology reports, 21(4), 887-891. https://doi.org/10.3892/or_00000299

Malignant melanoma with a rhabdoid phenotype exhibiting numerous solid tumor masses : A case report. / Nakamura, Tomoki; Matsumine, Akihiko; Kato, Hiroaki; Kusuzaki, Katsuyuki; Nishimura, Keisuke; Murata, Tetsuya; Shiraishi, Taizo; Oda, Yoshinao; Tsuneyoshi, Masazumi; Uchida, Atsumasa.

In: Oncology reports, Vol. 21, No. 4, 29.06.2009, p. 887-891.

Research output: Contribution to journalArticle

Nakamura, T, Matsumine, A, Kato, H, Kusuzaki, K, Nishimura, K, Murata, T, Shiraishi, T, Oda, Y, Tsuneyoshi, M & Uchida, A 2009, 'Malignant melanoma with a rhabdoid phenotype exhibiting numerous solid tumor masses: A case report', Oncology reports, vol. 21, no. 4, pp. 887-891. https://doi.org/10.3892/or_00000299
Nakamura T, Matsumine A, Kato H, Kusuzaki K, Nishimura K, Murata T et al. Malignant melanoma with a rhabdoid phenotype exhibiting numerous solid tumor masses: A case report. Oncology reports. 2009 Jun 29;21(4):887-891. https://doi.org/10.3892/or_00000299
Nakamura, Tomoki ; Matsumine, Akihiko ; Kato, Hiroaki ; Kusuzaki, Katsuyuki ; Nishimura, Keisuke ; Murata, Tetsuya ; Shiraishi, Taizo ; Oda, Yoshinao ; Tsuneyoshi, Masazumi ; Uchida, Atsumasa. / Malignant melanoma with a rhabdoid phenotype exhibiting numerous solid tumor masses : A case report. In: Oncology reports. 2009 ; Vol. 21, No. 4. pp. 887-891.
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