Malignant peripheral nerve sheath tumors presenting as spinal dumbbell tumors: clinical outcomes and characteristic imaging features

Yoshihiro Matsumoto, Makoto Endo, Katsumi Harimaya, Mitsumasa Hayashida, Toshio Doi, Yukihide Iwamoto

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Purpose: To investigate the clinical outcomes and imaging features of malignant peripheral nerve sheath tumors (MPNSTs) presenting as spinal dumbbell tumors. Methods: We retrospectively reviewed the clinical outcomes and imaging features of consecutive cases of spinal dumbbell MPNSTs (n = 8) and schwannomas (n = 15). Results: A maximal diameter >5 cm was more frequently seen in MPNSTs (88 %) than in schwannomas (14 %). Irregularly lobulated margins occurred frequently in MPNSTs (75 %), but not in schwannomas (21 %). Indistinguishable boundaries were observed in 63 % of MPNSTs, but only 7 % of schwannomas. Osteolytic bone destruction was found exclusively in MPNSTs (50 % of MPNSTs vs. 0 % of schwannomas). Conclusions: There is little clinical information relating to spinal dumbbell MPNSTs. We propose that the following imaging features are suggestive of spinal dumbbell MPNSTs: maximal diameter >5 cm, irregularly lobulated shape, boundary indistinguishable from surrounding tissues, and osteolytic bone destruction.

Original languageEnglish
Pages (from-to)2119-2125
Number of pages7
JournalEuropean Spine Journal
Volume24
Issue number10
DOIs
Publication statusPublished - Oct 1 2015

All Science Journal Classification (ASJC) codes

  • Surgery
  • Orthopedics and Sports Medicine

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