Malignant transformation of gastric hyperplastic polyps: Alteration of phenotypes, proliferative activity, and p53 expression

Takashi Yao, Masaaki Kajiwara, Sigekazu Kuroiwa, Akinori Iwashita, Masafumi Oya, Akira Kabashima, Masazumi Tsuneyoshi

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Abstract

The aim of this study was to clarify the mechanism of malignant transformation of gastric hyperplastic polyps, focusing on phenotypic expression, cell proliferation, and p53 overexpression. Twenty-two lesions of gastric hyperplastic polyps with neoplastic foci were selected for this study. The phenotypes were divided into 3 types (G, gastric; incomp I, incomplete intestinal; and comp I, complete intestinal), according to immunohistochemical stains (human gastric mucin [HGM], MUC2, and CD10). The cell proliferative activity by Ki-67 and overexpression of p53 protein were also examined. Eleven of these lesions contained carcinoma components (CA, category 5 by the Vienna classification), 6 of which were accompanied by low-grade dysplasia (LGD, category 3) and 4 of which were accompanied by high-grade dysplasia (HGD, category 4). Another 2 were composed only of HGD, and the remaining 9 were composed of both LGD and HGD components. As a result, 15 LGD, 15 HGD, and 11 CA components were recognized. The 15 LGD components were classified as 1 G type and 14 incomp I type. All hyperplastic components expressed HGM, 5 (22.7%) of which were accompanied by focal intesfinal metaplasia demonstrated by MUC2 expression, whereas intestinalization frequently occurred in neoplastic components (93% of LGD, 53% of HGD, and 64% of CA components). The labeling index was 22.2% in hyperplastic, 42.2% in LGD, 55.7% in HGD, and 53.9% in CA components. p53 protein overexpression was recognized in none of hyperplastic, in 40% of the LGD, in 60% of the HGD, and in 45% of the CA components. These results suggest the importance of the dysplasia-carcinoma sequence in malignant transformation of hyperplastic polyps. Interestingly, intestinalization frequently occurs during neoplastic transformation, although it is not common in the surrounding hyperplastic components.

Original languageEnglish
Pages (from-to)1016-1022
Number of pages7
JournalHuman Pathology
Volume33
Issue number10
DOIs
Publication statusPublished - Oct 2002

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Polyps
Gastric Mucins
Stomach
Phenotype
Carcinoma
Metaplasia
Proteins
Coloring Agents
Cell Proliferation

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Yao, T., Kajiwara, M., Kuroiwa, S., Iwashita, A., Oya, M., Kabashima, A., & Tsuneyoshi, M. (2002). Malignant transformation of gastric hyperplastic polyps: Alteration of phenotypes, proliferative activity, and p53 expression. Human Pathology, 33(10), 1016-1022. https://doi.org/10.1053/hupa.2002.126874

Malignant transformation of gastric hyperplastic polyps : Alteration of phenotypes, proliferative activity, and p53 expression. / Yao, Takashi; Kajiwara, Masaaki; Kuroiwa, Sigekazu; Iwashita, Akinori; Oya, Masafumi; Kabashima, Akira; Tsuneyoshi, Masazumi.

In: Human Pathology, Vol. 33, No. 10, 10.2002, p. 1016-1022.

Research output: Contribution to journalArticle

Yao, T, Kajiwara, M, Kuroiwa, S, Iwashita, A, Oya, M, Kabashima, A & Tsuneyoshi, M 2002, 'Malignant transformation of gastric hyperplastic polyps: Alteration of phenotypes, proliferative activity, and p53 expression', Human Pathology, vol. 33, no. 10, pp. 1016-1022. https://doi.org/10.1053/hupa.2002.126874
Yao, Takashi ; Kajiwara, Masaaki ; Kuroiwa, Sigekazu ; Iwashita, Akinori ; Oya, Masafumi ; Kabashima, Akira ; Tsuneyoshi, Masazumi. / Malignant transformation of gastric hyperplastic polyps : Alteration of phenotypes, proliferative activity, and p53 expression. In: Human Pathology. 2002 ; Vol. 33, No. 10. pp. 1016-1022.
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