TY - JOUR
T1 - Management of apnea in infants with trisomy 18
AU - Taira, Ryoji
AU - Inoue, Hirosuke
AU - Sawano, Toru
AU - Fujiyoshi, Junko
AU - Ichimiya, Yuko
AU - Torio, Michiko
AU - Sanefuji, Masafumi
AU - Ochiai, Masayuki
AU - Sakai, Yasunari
AU - Ohga, Shouichi
N1 - Funding Information:
This study was supported in part by JSPS KAKENHI Grant Numbers JP17K16300 (HI) and 19K08281 (YS); a Health and Labour Sciences Research Grant on Evidence‐based Early Diagnosis and Treatment Strategies for Neuroimmunological Diseases from the Ministry of Health, Labour and Welfare of Japan; and Kawano Masanori Memorial Public Interest Incorporated Foundation for Promotion of Pediatrics (YS). We are grateful to Drs. Yoshito Ishizaki, Tatsuya Korematsu, Tadamune Kinjo, and Yuri Sonoda (Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University) for discussion and comments that greatly improved this work as well as for suggestions to improve the clarity of the manuscript. The authors have stated that they had no interests that might be perceived as posing a conflict or bias.
Funding Information:
This study was supported in part by JSPS KAKENHI Grant Numbers JP17K16300 (HI) and 19K08281 (YS); a Health and Labour Sciences Research Grant on Evidence-based Early Diagnosis and Treatment Strategies for Neuroimmunological Diseases from the Ministry of Health, Labour and Welfare of Japan; and Kawano Masanori Memorial Public Interest Incorporated Foundation for Promotion of Pediatrics (YS). We are grateful to Drs. Yoshito Ishizaki, Tatsuya Korematsu, Tadamune Kinjo, and Yuri Sonoda (Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University) for discussion and comments that greatly improved this work as well as for suggestions to improve the clarity of the manuscript. The authors have stated that they had no interests that might be perceived as posing a conflict or bias.
Publisher Copyright:
© 2019 Mac Keith Press
PY - 2020/7/1
Y1 - 2020/7/1
N2 - This case series aimed to characterize the clinical features, management, and outcomes of apnea in infants with trisomy 18. Participants in this study were infants with trisomy 18 who were born alive and admitted to the neonatal intensive care unit in Kyushu University Hospital from 2000 to 2018. Retrospective analysis was performed on clinical data recorded in our department. Twenty-seven infants with trisomy 18 were admitted to our hospital during the study period, of which 25 (nine males, 16 females) were enrolled as eligible participants in this study. Among them, 14 started presenting with apnea from median 3.5 days of age (range 0–47d). In these infants with apnea, eight received respiratory support of positive pressure ventilation (PPV). The 1-year survival rate of infants in the PPV group was higher than that of non-PPV-supported infants (5 out of 8 vs 0 out of 6 infants). Five PPV-supported infants received a diagnosis of epilepsy, which was controlled by antiepileptic drugs. Postnatal respiratory intervention provides better prognosis in infants with trisomy 18. Improved survival leads to accurate diagnosis and treatment of apneic events in association with epilepsy. What this paper adds: Respiratory support is effective against apnea in infants with trisomy 18. Intervention with ventilation provides a higher chance of prolonged survival. Improved survival leads to the accurate diagnosis and treatment of epilepsy-associated apnea.
AB - This case series aimed to characterize the clinical features, management, and outcomes of apnea in infants with trisomy 18. Participants in this study were infants with trisomy 18 who were born alive and admitted to the neonatal intensive care unit in Kyushu University Hospital from 2000 to 2018. Retrospective analysis was performed on clinical data recorded in our department. Twenty-seven infants with trisomy 18 were admitted to our hospital during the study period, of which 25 (nine males, 16 females) were enrolled as eligible participants in this study. Among them, 14 started presenting with apnea from median 3.5 days of age (range 0–47d). In these infants with apnea, eight received respiratory support of positive pressure ventilation (PPV). The 1-year survival rate of infants in the PPV group was higher than that of non-PPV-supported infants (5 out of 8 vs 0 out of 6 infants). Five PPV-supported infants received a diagnosis of epilepsy, which was controlled by antiepileptic drugs. Postnatal respiratory intervention provides better prognosis in infants with trisomy 18. Improved survival leads to accurate diagnosis and treatment of apneic events in association with epilepsy. What this paper adds: Respiratory support is effective against apnea in infants with trisomy 18. Intervention with ventilation provides a higher chance of prolonged survival. Improved survival leads to the accurate diagnosis and treatment of epilepsy-associated apnea.
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U2 - 10.1111/dmcn.14403
DO - 10.1111/dmcn.14403
M3 - Article
C2 - 31763690
AN - SCOPUS:85075433359
SN - 0012-1622
VL - 62
SP - 874
EP - 878
JO - Developmental Medicine and Child Neurology
JF - Developmental Medicine and Child Neurology
IS - 7
ER -