Management of apnea in infants with trisomy 18

Ryoji Taira, Hirosuke Inoue, Toru Sawano, Junko Fujiyoshi, Yuko Ichimiya, Michiko Torio, Masafumi Sanefuji, Masayuki Ochiai, Yasunari Sakai, Shouichi Ohga

Research output: Contribution to journalArticle

Abstract

This case series aimed to characterize the clinical features, management, and outcomes of apnea in infants with trisomy 18. Participants in this study were infants with trisomy 18 who were born alive and admitted to the neonatal intensive care unit in Kyushu University Hospital from 2000 to 2018. Retrospective analysis was performed on clinical data recorded in our department. Twenty-seven infants with trisomy 18 were admitted to our hospital during the study period, of which 25 (nine males, 16 females) were enrolled as eligible participants in this study. Among them, 14 started presenting with apnea from median 3.5 days of age (range 0–47d). In these infants with apnea, eight received respiratory support of positive pressure ventilation (PPV). The 1-year survival rate of infants in the PPV group was higher than that of non-PPV-supported infants (5 out of 8 vs 0 out of 6 infants). Five PPV-supported infants received a diagnosis of epilepsy, which was controlled by antiepileptic drugs. Postnatal respiratory intervention provides better prognosis in infants with trisomy 18. Improved survival leads to accurate diagnosis and treatment of apneic events in association with epilepsy.

Original languageEnglish
JournalDevelopmental Medicine and Child Neurology
DOIs
Publication statusAccepted/In press - Jan 1 2019

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Apnea
Positive-Pressure Respiration
Epilepsy
Trisomy 18
Neonatal Intensive Care Units
Anticonvulsants
Ventilation
Pressure

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Management of apnea in infants with trisomy 18. / Taira, Ryoji; Inoue, Hirosuke; Sawano, Toru; Fujiyoshi, Junko; Ichimiya, Yuko; Torio, Michiko; Sanefuji, Masafumi; Ochiai, Masayuki; Sakai, Yasunari; Ohga, Shouichi.

In: Developmental Medicine and Child Neurology, 01.01.2019.

Research output: Contribution to journalArticle

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AU - Torio, Michiko

AU - Sanefuji, Masafumi

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