Management strategy for multifocal branch duct intraductal papillary mucinous neoplasms of the pancreas

Yasuhisa Mori, Ohtsuka Takao, Hiroshi Kono, Noboru Ideno, Teppei Aso, Yosuke Nagayoshi, Shunichi Takahata, Masafumi Nakamura, Kosei Ishigami, Shinichi Aishima, Yoshinao Oda, Masao Tanaka

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

OBJECTIVES: Branch duct intraductal papillary mucinous neoplasms of the pancreas (BD-IPMNs) often are composed of multifocal lesions. We aimed to clarify the clinicopathologic features of multifocal BD-IPMNs. METHODS: Medical records of 211 patients with BD-IPMNs (169 solitary and 42 multifocal) were retrospectively analyzed. We compared the pathological grade of resected IPMNs and the resulting clinical course between solitary and multifocal BD-IPMNs. RESULTS: Sixty-nine patients (54 with solitary and 15 with multifocal BD-IPMNs) underwent pancreatectomy, and of these patients, 62 exhibited at least 1 malignant predictor. There was no significant difference in the prevalence of malignancy in the resected BD-IPMNs between the 2 groups. In the remaining 142 patients who exhibited no malignant predictors, both groups demonstrated no differences in morphologic changes of BD-IPMNs. Seventeen distinct ductal carcinomas were identified in both groups, and there was no difference in the prevalence of ductal carcinoma between the 2 groups. Moreover, there was no significant difference in the disease-specific survival rate between the 2 groups. CONCLUSIONS: In patients with multifocal BD-IPMNs, resection is only warranted for lesions that exhibit malignancy predictors; moreover, closer attention to the potential presence or development of distinct ductal carcinoma in patients with multifocal and solitary BD-IPMNs is warranted.

Original languageEnglish
Pages (from-to)1008-1012
Number of pages5
JournalPancreas
Volume41
Issue number7
DOIs
Publication statusPublished - Oct 1 2012

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Pancreatic Neoplasms
Ductal Carcinoma
Pancreatectomy
Medical Records
Neoplasms
Survival Rate

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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Management strategy for multifocal branch duct intraductal papillary mucinous neoplasms of the pancreas. / Mori, Yasuhisa; Takao, Ohtsuka; Kono, Hiroshi; Ideno, Noboru; Aso, Teppei; Nagayoshi, Yosuke; Takahata, Shunichi; Nakamura, Masafumi; Ishigami, Kosei; Aishima, Shinichi; Oda, Yoshinao; Tanaka, Masao.

In: Pancreas, Vol. 41, No. 7, 01.10.2012, p. 1008-1012.

Research output: Contribution to journalArticle

Mori, Y, Takao, O, Kono, H, Ideno, N, Aso, T, Nagayoshi, Y, Takahata, S, Nakamura, M, Ishigami, K, Aishima, S, Oda, Y & Tanaka, M 2012, 'Management strategy for multifocal branch duct intraductal papillary mucinous neoplasms of the pancreas', Pancreas, vol. 41, no. 7, pp. 1008-1012. https://doi.org/10.1097/MPA.0b013e31824b22c6
Mori, Yasuhisa ; Takao, Ohtsuka ; Kono, Hiroshi ; Ideno, Noboru ; Aso, Teppei ; Nagayoshi, Yosuke ; Takahata, Shunichi ; Nakamura, Masafumi ; Ishigami, Kosei ; Aishima, Shinichi ; Oda, Yoshinao ; Tanaka, Masao. / Management strategy for multifocal branch duct intraductal papillary mucinous neoplasms of the pancreas. In: Pancreas. 2012 ; Vol. 41, No. 7. pp. 1008-1012.
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AU - Nakamura, Masafumi

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AB - OBJECTIVES: Branch duct intraductal papillary mucinous neoplasms of the pancreas (BD-IPMNs) often are composed of multifocal lesions. We aimed to clarify the clinicopathologic features of multifocal BD-IPMNs. METHODS: Medical records of 211 patients with BD-IPMNs (169 solitary and 42 multifocal) were retrospectively analyzed. We compared the pathological grade of resected IPMNs and the resulting clinical course between solitary and multifocal BD-IPMNs. RESULTS: Sixty-nine patients (54 with solitary and 15 with multifocal BD-IPMNs) underwent pancreatectomy, and of these patients, 62 exhibited at least 1 malignant predictor. There was no significant difference in the prevalence of malignancy in the resected BD-IPMNs between the 2 groups. In the remaining 142 patients who exhibited no malignant predictors, both groups demonstrated no differences in morphologic changes of BD-IPMNs. Seventeen distinct ductal carcinomas were identified in both groups, and there was no difference in the prevalence of ductal carcinoma between the 2 groups. Moreover, there was no significant difference in the disease-specific survival rate between the 2 groups. CONCLUSIONS: In patients with multifocal BD-IPMNs, resection is only warranted for lesions that exhibit malignancy predictors; moreover, closer attention to the potential presence or development of distinct ductal carcinoma in patients with multifocal and solitary BD-IPMNs is warranted.

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