Abstract
In the present study, tissue manganese superoxide dismutase (Mn-SOD) activities were determined postoperatively as a means to gauge future prognosis in oral squamous cell carcinoma (O-SCC). We investigated the relationships among the various clinico-pathologic parameters and clinical course of 43 patients with O-SCC. The Mn-SOD activity in the cancerous tissues decreased with the healthy controls, but there was no significant difference between the patients with O-SCC and healty controls. There was no significant difference between tissue Mn-SOD activities and clinical stage. However, patients who presented metastatic lymph nodes (N 1 or N 2) exhibited higher tissue Mn-SOD activities than patients without metastatic lymph nodes. In the pathologic parameters, the tissue Mn-SOD activities of grade 4 C, 4 D group and high histological malignancy group were significant higher than those of other groups. The tissue Mn-SOD activities were significantly lower in the good-prognosis group than in the poor-prognosis group. These results of the present study suggest that a evaluation of tissue Mn-SOD activities in O-SCC is a useful prognostic factor for screening of patients with O-SCC.
| Original language | English |
|---|---|
| Pages (from-to) | 321-327 |
| Number of pages | 7 |
| Journal | Fukuoka igaku zasshi = Hukuoka acta medica |
| Volume | 89 |
| Issue number | 11 |
| Publication status | Published - Jan 1 1998 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Medicine(all)