Maniçoba, a quercetin rich amazonian dish

Antioxidative prospects

Isao Kubo, Kuniyoshi Shimizu, Ken Ichi Nihei

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A large quantity of quercetin was characterized from a local dish, known as maniçoba in Pará, Brazil. The fresh leaf of Manihot esculenta Crantz (Euphorbiaceae), a principal ingredient for maniçoba, was found to contain a large amount of rutin or quercetin 3-O-rutinoside which was completely hydrolyzed to quercetin during cooking processes. Antioxidant activity of quercetin and its microfloral metabolites was examined. Quercetin inhibited the oxidation of linoleic acid catalyzed by soybean lipoxygenase-1 (EC 1.13.11.12, Type 1) with an IC50 of 4.5 μM, while rutin did not inhibit this oxidation up to 200 μM. The progress curves for the enzyme reaction indicate that quercetin shows slow binding kinetics. In the pseudoperoxidase activity, hydroperoxides slowly oxidize quercetin to a rather stable intermediate, 2-(3,4-dihydroxybenzoyl)-2,4,6-trihydroxy-3(2H)-benzofuranone. A microfloral metabolite of quercetin and rutin after ingestion, 3,4-dihydroxyphenylacetic acid, also scavenged superoxide anion generated by xanthine oxidase and inhibited uric acid formation. The antioxidant activity observed with the methanol extract of maniçoba is due mainly to multifunctional quercetin's response.

Original languageEnglish
Title of host publicationQuercetin: Dietary Sources, Functions and Health Benefits
PublisherNova Science Publishers, Inc.
Pages129-154
Number of pages26
ISBN (Print)9781619420571
Publication statusPublished - 2012
Externally publishedYes

Fingerprint

Quercetin
Rutin
Antioxidants
Euphorbiaceae
3,4-Dihydroxyphenylacetic Acid
Manihot
Xanthine Oxidase
Cooking
Linoleic Acid
Uric Acid
Superoxides
Hydrogen Peroxide
Inhibitory Concentration 50
Brazil
Methanol
Eating
Enzymes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kubo, I., Shimizu, K., & Nihei, K. I. (2012). Maniçoba, a quercetin rich amazonian dish: Antioxidative prospects. In Quercetin: Dietary Sources, Functions and Health Benefits (pp. 129-154). Nova Science Publishers, Inc..

Maniçoba, a quercetin rich amazonian dish : Antioxidative prospects. / Kubo, Isao; Shimizu, Kuniyoshi; Nihei, Ken Ichi.

Quercetin: Dietary Sources, Functions and Health Benefits. Nova Science Publishers, Inc., 2012. p. 129-154.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kubo, I, Shimizu, K & Nihei, KI 2012, Maniçoba, a quercetin rich amazonian dish: Antioxidative prospects. in Quercetin: Dietary Sources, Functions and Health Benefits. Nova Science Publishers, Inc., pp. 129-154.
Kubo I, Shimizu K, Nihei KI. Maniçoba, a quercetin rich amazonian dish: Antioxidative prospects. In Quercetin: Dietary Sources, Functions and Health Benefits. Nova Science Publishers, Inc. 2012. p. 129-154
Kubo, Isao ; Shimizu, Kuniyoshi ; Nihei, Ken Ichi. / Maniçoba, a quercetin rich amazonian dish : Antioxidative prospects. Quercetin: Dietary Sources, Functions and Health Benefits. Nova Science Publishers, Inc., 2012. pp. 129-154
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