TY - JOUR
T1 - Manipulation of the Lighting Schedule Can Modify the Pharmacological Effects of Theophylline In Chick Embryos
AU - Yoshiyama, Yuji
AU - Sugiyama, Takashi
AU - Kubota, Nobuo
AU - Miyazaki, Hiroyuki
AU - Saito, Kazuru
AU - Tomonaga, Fumiya
AU - Shimada, Hideyo
AU - Ohdo, Shigehiro
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1995
Y1 - 1995
N2 - The effect of the lighting schedule on the pharmacological action of theophylline was studied in chick embryos. Fertile eggs of White Leghorns were incubated and investigated, on two occasions, under constant light conditions or under constant dark conditions. A sigle injection of theophylline 2.14,4.29,8.57 and 17.14 mg/egg into the air sac of fertile eggs was carried out on the 16th day of incubation. Electrocardiograms (ECGs) were recorded 0 to 60 min after drug injection. After drug injection, heart rate increased under constant light conditions, but decreased under dark conditions. In addition, arrhythmia was produced by theophylline, 17.14mg/egg, under constant dark conditions. These results indicate that the manipulation of the lighting schedule may have a marked influence on the pharmacological effects of theophylline in chick embryos.
AB - The effect of the lighting schedule on the pharmacological action of theophylline was studied in chick embryos. Fertile eggs of White Leghorns were incubated and investigated, on two occasions, under constant light conditions or under constant dark conditions. A sigle injection of theophylline 2.14,4.29,8.57 and 17.14 mg/egg into the air sac of fertile eggs was carried out on the 16th day of incubation. Electrocardiograms (ECGs) were recorded 0 to 60 min after drug injection. After drug injection, heart rate increased under constant light conditions, but decreased under dark conditions. In addition, arrhythmia was produced by theophylline, 17.14mg/egg, under constant dark conditions. These results indicate that the manipulation of the lighting schedule may have a marked influence on the pharmacological effects of theophylline in chick embryos.
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U2 - 10.1248/bpb.18.776
DO - 10.1248/bpb.18.776
M3 - Article
C2 - 7492999
AN - SCOPUS:0029063533
VL - 18
SP - 776
EP - 778
JO - Biological and Pharmaceutical Bulletin
JF - Biological and Pharmaceutical Bulletin
SN - 0918-6158
IS - 5
ER -