TY - JOUR
T1 - Manniosides B-F, five new triterpenoid saponins from the leaves of Schefflera mannii (Hook.f.) Harms
AU - Ponou, Beaudelaire K.
AU - Tanaka, Chiaki
AU - Teponno, Rémy B.
AU - Tapondjou, Azefack L.
AU - Miyamoto, Tomofumi
N1 - Funding Information:
Dr. B. K. Ponou is grateful to The Matsumae International Foundation (MIF) for financing a postdoctoral research stay (6 months) at the Graduate School of Pharmaceutical Sciences, Kyushu University, Japan.
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/4
Y1 - 2021/4
N2 - Fifteen triterpenoid saponins including five new compounds (Mannioside B: 3β-[(β-D-glucopyranosyl)oxy]urs-12-en-28-oic acid α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyl ester (1), mannioside C: 3β-[(β-D-glucopyranosyl)23-dioxy]urs-12-en-28-oic acid α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyl ester (2), mannioside D: 3β,23-dihydroxyurs-12-en-28-oic acid β-D-glucopyranosyl-(1 → 6)- β-D-glucopyranosyl ester (3), mannioside E: 3β-hydroxy-23-oxolup-20(29)-en-28-oic acid α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyl ester (4) and mannioside F: (22S)-27β-[(β-D-glucopyranosyl)oxy]-22-hydroxyprotosta-12,24-dien-3β-yl β-D-glucopyranoside (5)) were isolated from the leaves of Schefflera mannii (Hook.f.) Harms. Their structures were established on the basis of 1D and 2D NMR data, mass spectrometry and chemical methods. The major isolated compounds were tested for their antiproliferative activity on human malignant epithelial (HeLa) cells but were not efficient at the concentration of 33 mM.
AB - Fifteen triterpenoid saponins including five new compounds (Mannioside B: 3β-[(β-D-glucopyranosyl)oxy]urs-12-en-28-oic acid α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyl ester (1), mannioside C: 3β-[(β-D-glucopyranosyl)23-dioxy]urs-12-en-28-oic acid α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyl ester (2), mannioside D: 3β,23-dihydroxyurs-12-en-28-oic acid β-D-glucopyranosyl-(1 → 6)- β-D-glucopyranosyl ester (3), mannioside E: 3β-hydroxy-23-oxolup-20(29)-en-28-oic acid α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyl ester (4) and mannioside F: (22S)-27β-[(β-D-glucopyranosyl)oxy]-22-hydroxyprotosta-12,24-dien-3β-yl β-D-glucopyranoside (5)) were isolated from the leaves of Schefflera mannii (Hook.f.) Harms. Their structures were established on the basis of 1D and 2D NMR data, mass spectrometry and chemical methods. The major isolated compounds were tested for their antiproliferative activity on human malignant epithelial (HeLa) cells but were not efficient at the concentration of 33 mM.
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U2 - 10.1016/j.carres.2021.108279
DO - 10.1016/j.carres.2021.108279
M3 - Article
C2 - 33691222
AN - SCOPUS:85101979985
SN - 0008-6215
VL - 502
JO - Carbohydrate Research
JF - Carbohydrate Research
M1 - 108279
ER -