Manniosides B-F, five new triterpenoid saponins from the leaves of Schefflera mannii (Hook.f.) Harms

Beaudelaire K. Ponou, Chiaki Tanaka, Rémy B. Teponno, Azefack L. Tapondjou, Tomofumi Miyamoto

Research output: Contribution to journalArticlepeer-review

Abstract

Fifteen triterpenoid saponins including five new compounds (Mannioside B: 3β-[(β-D-glucopyranosyl)oxy]urs-12-en-28-oic acid α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyl ester (1), mannioside C: 3β-[(β-D-glucopyranosyl)23-dioxy]urs-12-en-28-oic acid α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyl ester (2), mannioside D: 3β,23-dihydroxyurs-12-en-28-oic acid β-D-glucopyranosyl-(1 → 6)- β-D-glucopyranosyl ester (3), mannioside E: 3β-hydroxy-23-oxolup-20(29)-en-28-oic acid α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyl ester (4) and mannioside F: (22S)-27β-[(β-D-glucopyranosyl)oxy]-22-hydroxyprotosta-12,24-dien-3β-yl β-D-glucopyranoside (5)) were isolated from the leaves of Schefflera mannii (Hook.f.) Harms. Their structures were established on the basis of 1D and 2D NMR data, mass spectrometry and chemical methods. The major isolated compounds were tested for their antiproliferative activity on human malignant epithelial (HeLa) cells but were not efficient at the concentration of 33 mM.

Original languageEnglish
Article number108279
JournalCarbohydrate Research
Volume502
DOIs
Publication statusPublished - Apr 2021

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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