MAP-2e, a novel MAP-2 isoform, is expressed in gliomas and delineates tumor architecture and patterns of infiltration

Satoshi O. Suzuki, Ryuhei Kitai, Josephine Llena, Sunhee C. Lee, James E. Goldman, Bridget Shafit-Zagardo

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The MAP-2 isoform containing exon 13 (MAP-2e) is expressed in human fetal development as early as 15 gestational weeks and parallels oligodendrocyte maturation. MAP-2e is down-regulated following myelination and is expressed in few cells in the adult central nervous system (CNS). To determine whether CNS tumors express MAP-2e, we screened 122 archival, paraffin-embedded adult and pediatric tumors of the CNS and non-CNS. All oligodendrogliomas were positive and extensive staining was observed in glioblastomas, various malignant gliomas and dysembryoplastic neuroepithelial tumors. MAP-2e was not expressed in non-CNS tumors or neuroblastomas. Thus, neuroectodermal tumors that have glial characteristics express this developmental marker of immature glia. Analysis of oligodendrogliomas demonstrated numerous cell morphologies from round cells with no processes to cells with single or multiple processes. MAP-2e immunostaining also delineated tumor invasion into adjacent gray and white matter, indicating that MAP-2e appears to be a useful marker for examining the infiltration of malignant cells into surrounding tissue.

Original languageEnglish
Pages (from-to)403-412
Number of pages10
JournalJournal of neuropathology and experimental neurology
Volume61
Issue number5
DOIs
Publication statusPublished - Jan 1 2002
Externally publishedYes

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Glioma
Exons
Protein Isoforms
Oligodendroglioma
Central Nervous System Neoplasms
Neoplasms
Neuroglia
Neuroectodermal Tumors
Neuroepithelial Neoplasms
Nervous System Neoplasms
Oligodendroglia
Human Development
Glioblastoma
Fetal Development
Neuroblastoma
Paraffin
Nervous System
Central Nervous System
Pediatrics
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

MAP-2e, a novel MAP-2 isoform, is expressed in gliomas and delineates tumor architecture and patterns of infiltration. / Suzuki, Satoshi O.; Kitai, Ryuhei; Llena, Josephine; Lee, Sunhee C.; Goldman, James E.; Shafit-Zagardo, Bridget.

In: Journal of neuropathology and experimental neurology, Vol. 61, No. 5, 01.01.2002, p. 403-412.

Research output: Contribution to journalArticle

Suzuki, Satoshi O. ; Kitai, Ryuhei ; Llena, Josephine ; Lee, Sunhee C. ; Goldman, James E. ; Shafit-Zagardo, Bridget. / MAP-2e, a novel MAP-2 isoform, is expressed in gliomas and delineates tumor architecture and patterns of infiltration. In: Journal of neuropathology and experimental neurology. 2002 ; Vol. 61, No. 5. pp. 403-412.
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