Map kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans

Marc D. Meneghini, Tohru Ishitani, J. Clayton Carter, Naoki Hisamoto, Jun Ninomiya-Tsuji, Christopher J. Thorpe, Danlelle R. Hamill, Kunihiro Matsumoto, Bruce Bowerman

Research output: Contribution to journalArticle

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Abstract

The signalling protein Wnt regulates transcription factors containing high-mobility-group (HMG) domains to direct decisions on cell fate during animal development. In Caenorhabditis elegans, the HMG-domain-containing repressor POP-1 distinguishes the fates of anterior daughter cells from their posterior sisters throughout development, and Wnt signalling downregulates POP-1 activity in one posterior daughter cell called E (refs 2, 4, 5). Here we show that the genes more-4 and lit-1 are also required to downregulate POP-1, not only in E but also in other posterior daughter cells. Consistent with action in a common pathway, mom-4 and lit-1 exhibit similar mutant phenotypes and encode components of the mitogen-activated protein kinase (MAPK) pathway that are homologous to vertebrate transforming-growth-factor- β-activated kinase (TAK1) and NEMO-like kinase (NLK), respectively. Furthermore, MOM-4 and TAK1 bind related proteins that promote their kinase activities. We conclude that a MAPK-related pathway cooperates with Wnt signal transduction to downregulate POP-1 activity. These functions are likely to be conserved in vertebrates, as TAK1 and NLK can downregulate HMG- domain-containing proteins related to POP-1 (ref. 6).

Original languageEnglish
Pages (from-to)793-797
Number of pages5
JournalNature
Volume399
Issue number6738
DOIs
Publication statusPublished - Jun 24 1999

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Wnt Signaling Pathway
Caenorhabditis elegans
Phosphotransferases
Down-Regulation
Mitogen-Activated Protein Kinases
Vertebrates
Wnt Proteins
Transforming Growth Factors
Signal Transduction
Transcription Factors
Phenotype
Genes
Proteins

All Science Journal Classification (ASJC) codes

  • General

Cite this

Meneghini, M. D., Ishitani, T., Carter, J. C., Hisamoto, N., Ninomiya-Tsuji, J., Thorpe, C. J., ... Bowerman, B. (1999). Map kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans. Nature, 399(6738), 793-797. https://doi.org/10.1038/21666

Map kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans. / Meneghini, Marc D.; Ishitani, Tohru; Carter, J. Clayton; Hisamoto, Naoki; Ninomiya-Tsuji, Jun; Thorpe, Christopher J.; Hamill, Danlelle R.; Matsumoto, Kunihiro; Bowerman, Bruce.

In: Nature, Vol. 399, No. 6738, 24.06.1999, p. 793-797.

Research output: Contribution to journalArticle

Meneghini, MD, Ishitani, T, Carter, JC, Hisamoto, N, Ninomiya-Tsuji, J, Thorpe, CJ, Hamill, DR, Matsumoto, K & Bowerman, B 1999, 'Map kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans', Nature, vol. 399, no. 6738, pp. 793-797. https://doi.org/10.1038/21666
Meneghini MD, Ishitani T, Carter JC, Hisamoto N, Ninomiya-Tsuji J, Thorpe CJ et al. Map kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans. Nature. 1999 Jun 24;399(6738):793-797. https://doi.org/10.1038/21666
Meneghini, Marc D. ; Ishitani, Tohru ; Carter, J. Clayton ; Hisamoto, Naoki ; Ninomiya-Tsuji, Jun ; Thorpe, Christopher J. ; Hamill, Danlelle R. ; Matsumoto, Kunihiro ; Bowerman, Bruce. / Map kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans. In: Nature. 1999 ; Vol. 399, No. 6738. pp. 793-797.
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