TY - JOUR
T1 - MAP kinase cascades in antigen receptor signaling and physiology
AU - Yasuda, Tomoharu
N1 - Publisher Copyright:
© Springer International Publishing Switzerland 2015.
PY - 2015/8/15
Y1 - 2015/8/15
N2 - Mitogen-activated protein kinases (MAPKs) play roles in a cell type and context-dependent manner to convert extracellular stimuli to a variety of cellular responses, thereby directing cells to proliferation, differentiation, survival, apoptosis, and migration. Studies of genetically engineered mice or chemical inhibitors specific to each MAPK signaling pathway revealed that MAPKs have various, but non-redundant physiologically important roles among different families. MAPK cascades are obviously integrated in the B cell receptor signaling pathways as critical components to drive B cell-mediated immunity.
AB - Mitogen-activated protein kinases (MAPKs) play roles in a cell type and context-dependent manner to convert extracellular stimuli to a variety of cellular responses, thereby directing cells to proliferation, differentiation, survival, apoptosis, and migration. Studies of genetically engineered mice or chemical inhibitors specific to each MAPK signaling pathway revealed that MAPKs have various, but non-redundant physiologically important roles among different families. MAPK cascades are obviously integrated in the B cell receptor signaling pathways as critical components to drive B cell-mediated immunity.
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U2 - 10.1007/82_2015_481
DO - 10.1007/82_2015_481
M3 - Article
C2 - 26275875
AN - SCOPUS:84952326401
VL - 393
SP - 211
EP - 231
JO - Ergebnisse der Hygiene, Bakteriologie, Immunitätsforschung und experimentellen Therapie
JF - Ergebnisse der Hygiene, Bakteriologie, Immunitätsforschung und experimentellen Therapie
SN - 0070-217X
ER -