MAP kinase cascades in antigen receptor signaling and physiology

Tomoharu Yasuda

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Mitogen-activated protein kinases (MAPKs) play roles in a cell type and context-dependent manner to convert extracellular stimuli to a variety of cellular responses, thereby directing cells to proliferation, differentiation, survival, apoptosis, and migration. Studies of genetically engineered mice or chemical inhibitors specific to each MAPK signaling pathway revealed that MAPKs have various, but non-redundant physiologically important roles among different families. MAPK cascades are obviously integrated in the B cell receptor signaling pathways as critical components to drive B cell-mediated immunity.

Original languageEnglish
Pages (from-to)211-231
Number of pages21
JournalCurrent Topics in Microbiology and Immunology
Volume393
DOIs
Publication statusPublished - Aug 15 2015

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

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