MAP kinase cascades in antigen receptor signaling and physiology

Tomoharu Yasuda

doi:10.1007/82_2015_481

MAP kinase cascades in antigen receptor signaling and physiology

Tomoharu Yasuda

Department of Molecular and Structural Biology

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Mitogen-activated protein kinases (MAPKs) play roles in a cell type and context-dependent manner to convert extracellular stimuli to a variety of cellular responses, thereby directing cells to proliferation, differentiation, survival, apoptosis, and migration. Studies of genetically engineered mice or chemical inhibitors specific to each MAPK signaling pathway revealed that MAPKs have various, but non-redundant physiologically important roles among different families. MAPK cascades are obviously integrated in the B cell receptor signaling pathways as critical components to drive B cell-mediated immunity.

Original language	English
Pages (from-to)	211-231
Number of pages	21
Journal	Current Topics in Microbiology and Immunology
Volume	393
DOIs	https://doi.org/10.1007/82_2015_481
Publication status	Published - Aug 15 2015

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Microbiology
Immunology
Microbiology (medical)

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