Mapping of transregulatory domains of pseudorabies virus early protein 0 and identification of its dominant-negative mutant

S. Watanabe, Etsuro Ono, Y. Shimizu, H. Kida

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Pseudorabies virus (PRV) early protein 0 (EP0) is a transactivator containing the RING finger domain. Analysis of transactivating activity of truncated forms of the EP0 molecule consisting of 410 amino acids revealed that amino-terminal region containing the RING finger domain, amino acids 1 to 84, and the region between amino acids 114 to 242 containing acidic amino acid sequences were required for the transactivation. On the other hand, the mutant consisting of amino acids 1 to 113 exhibited a dominant- negative property.

Original languageEnglish
Pages (from-to)1001-1009
Number of pages9
JournalArchives of Virology
Volume141
Issue number6
DOIs
Publication statusPublished - Jan 1 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Virology

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