Mapping quantitative trait loci affecting circadian photosensitivity in retinally degenerate mice

Takashi Yoshimura, Yuki Yokota, Akira Ishikawa, Shinobu Yasuo, Noriko Hayashi, Tohru Suzuki, Naritoshi Okabayashi, Takao Namikawa, Shizufumi Ebihara

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

It is known that retinally degenerate C57BL/6J (rd/rd) mice have unattenuated circadian photosensitivity. However, the authors have previously found that CBA/J (rd/rd) mice that carry the same rd mutation have attenuated circadian photosensitivity compared to normal CBA/N (+/+) mice. In the present study, a quantitative trait locus (QTL) analysis using C57BL/6J (rd/rd) and CBA/J (rd/rd) mice was conducted in order to identify the genes affecting circadian photosensitivity of the rd mice. As a result, several putative QTLs on three separate chromosomes (8, 12, 17) were detected, which indicates that circadian photosensitivity in rd mice is altered by multiple genes. Identification of these genes may provide new insights into the understanding of regulation of circadian photoentrainment and sleep-wake disorders.

Original languageEnglish
Pages (from-to)512-519
Number of pages8
JournalJournal of Biological Rhythms
Volume17
Issue number6
DOIs
Publication statusPublished - Dec 1 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

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