Markers for Guillain-Barré syndrome with poor prognosis: a multi-center study

Yuko Yamagishi, Hidekazu Suzuki, Masahiro Sonoo, Satoshi Kuwabara, Takanori Yokota, Kyoichi Nomura, Atsuro Chiba, Ryuji Kaji, Takashi Kanda, Kenichi Kaida, Shu Ichi Ikeda, Tatsuro Mutoh, Ryo Yamasaki, Hiroshi Takashima, Makoto Matsui, Kazutoshi Nishiyama, Gen Sobue, Susumu Kusunoki

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Guillain-Barré syndrome (GBS) is an acute monophasic neuropathy. Prognostic tools include the modified Erasmus GBS outcome score (mEGOS), Erasmus GBS respiratory insufficiency score (EGRIS), and the increase in serum IgG levels (ΔIgG) 2 weeks after intravenous immunoglobulin (IVIg) treatment. Given that proportions of GBS subtypes differ between Western countries and Japan, the usefulness of these tools in Japan or other countries remains unknown. We enrolled 177 Japanese patients with GBS from 15 university hospitals and retrospectively obtained mEGOS and EGRIS for all and ΔIgG status for 79 of them. High mEGOS scores on admission or on day 7 were significantly associated with poorer outcomes (unable to walk independently at 6 months). High EGRIS scores (≥5 points) were associated with an increased risk for mechanical ventilation. Patients with ΔIgG <1,108 mg/dl had significantly poorer outcomes. We suggest that mEGOS, EGRIS, and ΔIgG in GBS are clinically relevant in Japan.

Original languageEnglish
Pages (from-to)433-439
Number of pages7
JournalJournal of the Peripheral Nervous System
Volume22
Issue number4
DOIs
Publication statusPublished - Dec 1 2017

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Immunoglobulin G
Respiratory Insufficiency
Japan
Intravenous Immunoglobulins
Artificial Respiration
Serum
Therapeutics

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Yamagishi, Y., Suzuki, H., Sonoo, M., Kuwabara, S., Yokota, T., Nomura, K., ... Kusunoki, S. (2017). Markers for Guillain-Barré syndrome with poor prognosis: a multi-center study. Journal of the Peripheral Nervous System, 22(4), 433-439. https://doi.org/10.1111/jns.12234

Markers for Guillain-Barré syndrome with poor prognosis : a multi-center study. / Yamagishi, Yuko; Suzuki, Hidekazu; Sonoo, Masahiro; Kuwabara, Satoshi; Yokota, Takanori; Nomura, Kyoichi; Chiba, Atsuro; Kaji, Ryuji; Kanda, Takashi; Kaida, Kenichi; Ikeda, Shu Ichi; Mutoh, Tatsuro; Yamasaki, Ryo; Takashima, Hiroshi; Matsui, Makoto; Nishiyama, Kazutoshi; Sobue, Gen; Kusunoki, Susumu.

In: Journal of the Peripheral Nervous System, Vol. 22, No. 4, 01.12.2017, p. 433-439.

Research output: Contribution to journalArticle

Yamagishi, Y, Suzuki, H, Sonoo, M, Kuwabara, S, Yokota, T, Nomura, K, Chiba, A, Kaji, R, Kanda, T, Kaida, K, Ikeda, SI, Mutoh, T, Yamasaki, R, Takashima, H, Matsui, M, Nishiyama, K, Sobue, G & Kusunoki, S 2017, 'Markers for Guillain-Barré syndrome with poor prognosis: a multi-center study', Journal of the Peripheral Nervous System, vol. 22, no. 4, pp. 433-439. https://doi.org/10.1111/jns.12234
Yamagishi, Yuko ; Suzuki, Hidekazu ; Sonoo, Masahiro ; Kuwabara, Satoshi ; Yokota, Takanori ; Nomura, Kyoichi ; Chiba, Atsuro ; Kaji, Ryuji ; Kanda, Takashi ; Kaida, Kenichi ; Ikeda, Shu Ichi ; Mutoh, Tatsuro ; Yamasaki, Ryo ; Takashima, Hiroshi ; Matsui, Makoto ; Nishiyama, Kazutoshi ; Sobue, Gen ; Kusunoki, Susumu. / Markers for Guillain-Barré syndrome with poor prognosis : a multi-center study. In: Journal of the Peripheral Nervous System. 2017 ; Vol. 22, No. 4. pp. 433-439.
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