Abstract
Objectives: To evaluate the relationship between the enhancement pattern of intrahepatic cholangiocarcinomas (ICCs) in the hepatic arterial phase (HAP) of dynamic hepatic CT and the clinicopathological findings with special reference to the perihilar type and the peripheral type. Methods: Forty-seven patients with pathologically proven ICCs were enrolled. Based on the enhancement pattern in the HAP, the lesions were classified into three groups: a hypovascular group (n=13), rim-enhancement group (n=18), and hypervascular group (n=16). The clinicopathological findings were compared among the three groups. Results: Perihilar-type ICCs were significantly more frequently observed in the hypovascular group than in the rim-enhancement and hypervascular groups (p=0.006 and p <0.001, respectively). Lymphatic invasion, perineural invasion, and biliary invasion were significantly more frequent in the hypovascular group than the rim- enhancement group (p=0.001, p=0.025 and p=0.029, respectively) or hypervascular group (p <0.001, p <0.001 and p=0.025, respectively). Patients with hypovascular lesions showed significantly poorer disease-free survival than patients with rim-enhancing or hypervascular lesions (p=0.001 and p=0.001, respectively). Hypovascularity was an independent preoperative prognostic factor for disease-free survival (p<0.001). Conclusions: Hypovascular ICCs in the HAP tend to be of perihilar type and to have more malignant potential than other ICCs. Key Points: • Hypovascular ICCs have greater malignant potential than rim-enhancing and hypervascular ICCs. • Hypovascular ICCs show a higher frequency of perihilar-type ICCs. • Perihilar-type ICCs do not always display distal ductal wall thickening.
| Original language | English |
|---|---|
| Pages (from-to) | 498-506 |
| Number of pages | 9 |
| Journal | European Radiology |
| Volume | 27 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 1 2017 |
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All Science Journal Classification (ASJC) codes
- Radiology Nuclear Medicine and imaging
Cite this
Mass-forming intrahepatic cholangiocarcinoma : Enhancement patterns in the arterial phase of dynamic hepatic CT - Correlation with clinicopathological findings. / Fujita, Nobuhiro; Asayama, Yoshiki; Nishie, Akihiro; Ishigami, Kousei; Ushijima, Yasuhiro; Takayama, Yukihisa; Okamoto, Daisuke; Moirta, Koichiro; Shirabe, Ken; Aishima, Shinichi; Wang, Huanlin; Oda, Yoshinao; Honda, Hiroshi.
In: European Radiology, Vol. 27, No. 2, 01.02.2017, p. 498-506.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mass-forming intrahepatic cholangiocarcinoma
T2 - Enhancement patterns in the arterial phase of dynamic hepatic CT - Correlation with clinicopathological findings
AU - Fujita, Nobuhiro
AU - Asayama, Yoshiki
AU - Nishie, Akihiro
AU - Ishigami, Kousei
AU - Ushijima, Yasuhiro
AU - Takayama, Yukihisa
AU - Okamoto, Daisuke
AU - Moirta, Koichiro
AU - Shirabe, Ken
AU - Aishima, Shinichi
AU - Wang, Huanlin
AU - Oda, Yoshinao
AU - Honda, Hiroshi
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Objectives: To evaluate the relationship between the enhancement pattern of intrahepatic cholangiocarcinomas (ICCs) in the hepatic arterial phase (HAP) of dynamic hepatic CT and the clinicopathological findings with special reference to the perihilar type and the peripheral type. Methods: Forty-seven patients with pathologically proven ICCs were enrolled. Based on the enhancement pattern in the HAP, the lesions were classified into three groups: a hypovascular group (n=13), rim-enhancement group (n=18), and hypervascular group (n=16). The clinicopathological findings were compared among the three groups. Results: Perihilar-type ICCs were significantly more frequently observed in the hypovascular group than in the rim-enhancement and hypervascular groups (p=0.006 and p <0.001, respectively). Lymphatic invasion, perineural invasion, and biliary invasion were significantly more frequent in the hypovascular group than the rim- enhancement group (p=0.001, p=0.025 and p=0.029, respectively) or hypervascular group (p <0.001, p <0.001 and p=0.025, respectively). Patients with hypovascular lesions showed significantly poorer disease-free survival than patients with rim-enhancing or hypervascular lesions (p=0.001 and p=0.001, respectively). Hypovascularity was an independent preoperative prognostic factor for disease-free survival (p<0.001). Conclusions: Hypovascular ICCs in the HAP tend to be of perihilar type and to have more malignant potential than other ICCs. Key Points: • Hypovascular ICCs have greater malignant potential than rim-enhancing and hypervascular ICCs. • Hypovascular ICCs show a higher frequency of perihilar-type ICCs. • Perihilar-type ICCs do not always display distal ductal wall thickening.
AB - Objectives: To evaluate the relationship between the enhancement pattern of intrahepatic cholangiocarcinomas (ICCs) in the hepatic arterial phase (HAP) of dynamic hepatic CT and the clinicopathological findings with special reference to the perihilar type and the peripheral type. Methods: Forty-seven patients with pathologically proven ICCs were enrolled. Based on the enhancement pattern in the HAP, the lesions were classified into three groups: a hypovascular group (n=13), rim-enhancement group (n=18), and hypervascular group (n=16). The clinicopathological findings were compared among the three groups. Results: Perihilar-type ICCs were significantly more frequently observed in the hypovascular group than in the rim-enhancement and hypervascular groups (p=0.006 and p <0.001, respectively). Lymphatic invasion, perineural invasion, and biliary invasion were significantly more frequent in the hypovascular group than the rim- enhancement group (p=0.001, p=0.025 and p=0.029, respectively) or hypervascular group (p <0.001, p <0.001 and p=0.025, respectively). Patients with hypovascular lesions showed significantly poorer disease-free survival than patients with rim-enhancing or hypervascular lesions (p=0.001 and p=0.001, respectively). Hypovascularity was an independent preoperative prognostic factor for disease-free survival (p<0.001). Conclusions: Hypovascular ICCs in the HAP tend to be of perihilar type and to have more malignant potential than other ICCs. Key Points: • Hypovascular ICCs have greater malignant potential than rim-enhancing and hypervascular ICCs. • Hypovascular ICCs show a higher frequency of perihilar-type ICCs. • Perihilar-type ICCs do not always display distal ductal wall thickening.
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U2 - 10.1007/s00330-016-4386-3
DO - 10.1007/s00330-016-4386-3
M3 - Article
C2 - 27165138
AN - SCOPUS:84966508514
VL - 27
SP - 498
EP - 506
JO - European Radiology
JF - European Radiology
SN - 0938-7994
IS - 2
ER -