Mass-forming intrahepatic cholangiocarcinoma

Enhancement patterns in the arterial phase of dynamic hepatic CT - Correlation with clinicopathological findings

Nobuhiro Fujita, Yoshiki Asayama, Akihiro Nishie, Kousei Ishigami, yasuhiro ushijima, Yukihisa Takayama, Daisuke Okamoto, Koichiro Moirta, Ken Shirabe, Shinichi Aishima, Huanlin Wang, Yoshinao Oda, Hiroshi Honda

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objectives: To evaluate the relationship between the enhancement pattern of intrahepatic cholangiocarcinomas (ICCs) in the hepatic arterial phase (HAP) of dynamic hepatic CT and the clinicopathological findings with special reference to the perihilar type and the peripheral type. Methods: Forty-seven patients with pathologically proven ICCs were enrolled. Based on the enhancement pattern in the HAP, the lesions were classified into three groups: a hypovascular group (n=13), rim-enhancement group (n=18), and hypervascular group (n=16). The clinicopathological findings were compared among the three groups. Results: Perihilar-type ICCs were significantly more frequently observed in the hypovascular group than in the rim-enhancement and hypervascular groups (p=0.006 and p <0.001, respectively). Lymphatic invasion, perineural invasion, and biliary invasion were significantly more frequent in the hypovascular group than the rim- enhancement group (p=0.001, p=0.025 and p=0.029, respectively) or hypervascular group (p <0.001, p <0.001 and p=0.025, respectively). Patients with hypovascular lesions showed significantly poorer disease-free survival than patients with rim-enhancing or hypervascular lesions (p=0.001 and p=0.001, respectively). Hypovascularity was an independent preoperative prognostic factor for disease-free survival (p<0.001). Conclusions: Hypovascular ICCs in the HAP tend to be of perihilar type and to have more malignant potential than other ICCs. Key Points: • Hypovascular ICCs have greater malignant potential than rim-enhancing and hypervascular ICCs. • Hypovascular ICCs show a higher frequency of perihilar-type ICCs. • Perihilar-type ICCs do not always display distal ductal wall thickening.

Original languageEnglish
Pages (from-to)498-506
Number of pages9
JournalEuropean Radiology
Volume27
Issue number2
DOIs
Publication statusPublished - Feb 1 2017

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Cholangiocarcinoma
Liver
Klatskin Tumor
Disease-Free Survival

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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Mass-forming intrahepatic cholangiocarcinoma : Enhancement patterns in the arterial phase of dynamic hepatic CT - Correlation with clinicopathological findings. / Fujita, Nobuhiro; Asayama, Yoshiki; Nishie, Akihiro; Ishigami, Kousei; ushijima, yasuhiro; Takayama, Yukihisa; Okamoto, Daisuke; Moirta, Koichiro; Shirabe, Ken; Aishima, Shinichi; Wang, Huanlin; Oda, Yoshinao; Honda, Hiroshi.

In: European Radiology, Vol. 27, No. 2, 01.02.2017, p. 498-506.

Research output: Contribution to journalArticle

Fujita, Nobuhiro ; Asayama, Yoshiki ; Nishie, Akihiro ; Ishigami, Kousei ; ushijima, yasuhiro ; Takayama, Yukihisa ; Okamoto, Daisuke ; Moirta, Koichiro ; Shirabe, Ken ; Aishima, Shinichi ; Wang, Huanlin ; Oda, Yoshinao ; Honda, Hiroshi. / Mass-forming intrahepatic cholangiocarcinoma : Enhancement patterns in the arterial phase of dynamic hepatic CT - Correlation with clinicopathological findings. In: European Radiology. 2017 ; Vol. 27, No. 2. pp. 498-506.
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abstract = "Objectives: To evaluate the relationship between the enhancement pattern of intrahepatic cholangiocarcinomas (ICCs) in the hepatic arterial phase (HAP) of dynamic hepatic CT and the clinicopathological findings with special reference to the perihilar type and the peripheral type. Methods: Forty-seven patients with pathologically proven ICCs were enrolled. Based on the enhancement pattern in the HAP, the lesions were classified into three groups: a hypovascular group (n=13), rim-enhancement group (n=18), and hypervascular group (n=16). The clinicopathological findings were compared among the three groups. Results: Perihilar-type ICCs were significantly more frequently observed in the hypovascular group than in the rim-enhancement and hypervascular groups (p=0.006 and p <0.001, respectively). Lymphatic invasion, perineural invasion, and biliary invasion were significantly more frequent in the hypovascular group than the rim- enhancement group (p=0.001, p=0.025 and p=0.029, respectively) or hypervascular group (p <0.001, p <0.001 and p=0.025, respectively). Patients with hypovascular lesions showed significantly poorer disease-free survival than patients with rim-enhancing or hypervascular lesions (p=0.001 and p=0.001, respectively). Hypovascularity was an independent preoperative prognostic factor for disease-free survival (p<0.001). Conclusions: Hypovascular ICCs in the HAP tend to be of perihilar type and to have more malignant potential than other ICCs. Key Points: • Hypovascular ICCs have greater malignant potential than rim-enhancing and hypervascular ICCs. • Hypovascular ICCs show a higher frequency of perihilar-type ICCs. • Perihilar-type ICCs do not always display distal ductal wall thickening.",
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T2 - Enhancement patterns in the arterial phase of dynamic hepatic CT - Correlation with clinicopathological findings

AU - Fujita, Nobuhiro

AU - Asayama, Yoshiki

AU - Nishie, Akihiro

AU - Ishigami, Kousei

AU - ushijima, yasuhiro

AU - Takayama, Yukihisa

AU - Okamoto, Daisuke

AU - Moirta, Koichiro

AU - Shirabe, Ken

AU - Aishima, Shinichi

AU - Wang, Huanlin

AU - Oda, Yoshinao

AU - Honda, Hiroshi

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Objectives: To evaluate the relationship between the enhancement pattern of intrahepatic cholangiocarcinomas (ICCs) in the hepatic arterial phase (HAP) of dynamic hepatic CT and the clinicopathological findings with special reference to the perihilar type and the peripheral type. Methods: Forty-seven patients with pathologically proven ICCs were enrolled. Based on the enhancement pattern in the HAP, the lesions were classified into three groups: a hypovascular group (n=13), rim-enhancement group (n=18), and hypervascular group (n=16). The clinicopathological findings were compared among the three groups. Results: Perihilar-type ICCs were significantly more frequently observed in the hypovascular group than in the rim-enhancement and hypervascular groups (p=0.006 and p <0.001, respectively). Lymphatic invasion, perineural invasion, and biliary invasion were significantly more frequent in the hypovascular group than the rim- enhancement group (p=0.001, p=0.025 and p=0.029, respectively) or hypervascular group (p <0.001, p <0.001 and p=0.025, respectively). Patients with hypovascular lesions showed significantly poorer disease-free survival than patients with rim-enhancing or hypervascular lesions (p=0.001 and p=0.001, respectively). Hypovascularity was an independent preoperative prognostic factor for disease-free survival (p<0.001). Conclusions: Hypovascular ICCs in the HAP tend to be of perihilar type and to have more malignant potential than other ICCs. Key Points: • Hypovascular ICCs have greater malignant potential than rim-enhancing and hypervascular ICCs. • Hypovascular ICCs show a higher frequency of perihilar-type ICCs. • Perihilar-type ICCs do not always display distal ductal wall thickening.

AB - Objectives: To evaluate the relationship between the enhancement pattern of intrahepatic cholangiocarcinomas (ICCs) in the hepatic arterial phase (HAP) of dynamic hepatic CT and the clinicopathological findings with special reference to the perihilar type and the peripheral type. Methods: Forty-seven patients with pathologically proven ICCs were enrolled. Based on the enhancement pattern in the HAP, the lesions were classified into three groups: a hypovascular group (n=13), rim-enhancement group (n=18), and hypervascular group (n=16). The clinicopathological findings were compared among the three groups. Results: Perihilar-type ICCs were significantly more frequently observed in the hypovascular group than in the rim-enhancement and hypervascular groups (p=0.006 and p <0.001, respectively). Lymphatic invasion, perineural invasion, and biliary invasion were significantly more frequent in the hypovascular group than the rim- enhancement group (p=0.001, p=0.025 and p=0.029, respectively) or hypervascular group (p <0.001, p <0.001 and p=0.025, respectively). Patients with hypovascular lesions showed significantly poorer disease-free survival than patients with rim-enhancing or hypervascular lesions (p=0.001 and p=0.001, respectively). Hypovascularity was an independent preoperative prognostic factor for disease-free survival (p<0.001). Conclusions: Hypovascular ICCs in the HAP tend to be of perihilar type and to have more malignant potential than other ICCs. Key Points: • Hypovascular ICCs have greater malignant potential than rim-enhancing and hypervascular ICCs. • Hypovascular ICCs show a higher frequency of perihilar-type ICCs. • Perihilar-type ICCs do not always display distal ductal wall thickening.

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