Mass Fragmentographic Determination of γ‐Aminobutyric Acid and Glutamic Acid in Discrete Amygdaloid Nuclei of Rat Brain

Kaoru Nakamura; Takashi Matsumoto; Makoto Hirano; Hiroshi Kagoshima; Toshihide Kuroki; Hiroshi Yao; Hideyuki Uchimura; Tatsuo Nakahara

doi:10.1111/j.1471-4159.1987.tb05745.x

Mass Fragmentographic Determination of γ‐Aminobutyric Acid and Glutamic Acid in Discrete Amygdaloid Nuclei of Rat Brain

Kaoru Nakamura, Takashi Matsumoto, Makoto Hirano, Hiroshi Kagoshima, Toshihide Kuroki, Hiroshi Yao, Hideyuki Uchimura, Tatsuo Nakahara

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Abstract: A mass fragmentographic method for the simultaneous quantification of γ‐aminobutyric acid (GABA) and glutamic acid is described. In a convenient one‐step reaction, the two ammo acids were derivatized with pentafluor‐opropionic anhydride and pentafluoropropanol. The deri‐vatization products were stable for several days. The technique has been applied to the assay of GABA and Glu in five amygdaloid nuclei of the rat brain. The GABA level was high in the central and medial nuclei, whereas the Glu level was high in the lateral and basal nuclei. The regional distribution of GABA was different from that of Glu within the amygdaloid nuclei.

Original language	English
Pages (from-to)	1842-1844
Number of pages	3
Journal	Journal of Neurochemistry
Volume	48
Issue number	6
DOIs	https://doi.org/10.1111/j.1471-4159.1987.tb05745.x
Publication status	Published - Jun 1987
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Cellular and Molecular Neuroscience

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10.1111/j.1471-4159.1987.tb05745.x

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Mass Fragmentographic Determination of γ‐Aminobutyric Acid and Glutamic Acid in Discrete Amygdaloid Nuclei of Rat Brain. / Nakamura, Kaoru; Matsumoto, Takashi; Hirano, Makoto; Kagoshima, Hiroshi; Kuroki, Toshihide; Yao, Hiroshi; Uchimura, Hideyuki; Nakahara, Tatsuo.

In: Journal of Neurochemistry, Vol. 48, No. 6, 06.1987, p. 1842-1844.

Research output: Contribution to journal › Article › peer-review

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abstract = "Abstract: A mass fragmentographic method for the simultaneous quantification of γ‐aminobutyric acid (GABA) and glutamic acid is described. In a convenient one‐step reaction, the two ammo acids were derivatized with pentafluor‐opropionic anhydride and pentafluoropropanol. The deri‐vatization products were stable for several days. The technique has been applied to the assay of GABA and Glu in five amygdaloid nuclei of the rat brain. The GABA level was high in the central and medial nuclei, whereas the Glu level was high in the lateral and basal nuclei. The regional distribution of GABA was different from that of Glu within the amygdaloid nuclei.",

author = "Kaoru Nakamura and Takashi Matsumoto and Makoto Hirano and Hiroshi Kagoshima and Toshihide Kuroki and Hiroshi Yao and Hideyuki Uchimura and Tatsuo Nakahara",

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AU - Kagoshima, Hiroshi

AU - Kuroki, Toshihide

AU - Yao, Hiroshi

AU - Uchimura, Hideyuki

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