Mass spectrometry methods for the analysis of bioactive sphingolipids: A high- performance liquid chromatography/tandem mass spectrometry approach

Jacek Bielawski, Motohiro Tani, Yusuf A. Hannun

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Sphingolipids (SPL), the general name for lipids containing a sphingoid long-chain base, are one of the most chemically and functionally diverse classes of biomolecules [1]. Sphingomyelin (SM) and glycosphingolipids (GSPL) constitute the major complex SPL in mammalian cells, both of which contain Cer as a lipid portion and phosphorylcholine or sugars, respectively, as a hydrophilic moiety. Cer, composed of a sphingoid base (SB) and an amide-linked fatty acid (FA), serves as the precursor for almost all SPL [1].

Original languageEnglish
Title of host publicationLipid-Mediated Signaling
PublisherCRC Press
Pages177-198
Number of pages22
ISBN (Electronic)9780849381423
ISBN (Print)9780849381416
DOIs
Publication statusPublished - Jan 1 2010
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Social Sciences(all)

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