TY - GEN
T1 - Material-driven fibronectin fibrillogenesis
AU - Cantini, Marco
AU - González-García, Cristina
AU - Llopis-Hernández, Virginia
AU - Salmerón-Sánchez, Manuel
N1 - Funding Information:
Acknowledgements. This work was supported by the Directorate General for International Cooperation (The Netherlands) for PhD scholarship under a collaborative project between ICIPE’s Biological Control of Cereal Stem Borers and Wageningen Agricultural University. We thank Julius Obonyo and Gerphas Okuku for their help during the ovary dissections. We also thank James Kabii for his assistance in setting up the electrophoresis apparatus in the molecular biology lab.
PY - 2012/12/12
Y1 - 2012/12/12
N2 - Material-driven fibronectin fibrillogenesis is a novel route to engineer the network structure and biological activity of fibronectin fibrillar matrices in analogy with their physiological cell-mediated assembly. We identify specific surface chemistries that promote the cell-free formation of physiological-like fibronectin fibrils in a time- and concentration-dependent process. Our most recent and relevant results, reviewed in the chapter, demonstrate the role of this material-induced fibrillogenesis in cell adhesion, extracellular matrix organization and degradation, and cell differentiation.
AB - Material-driven fibronectin fibrillogenesis is a novel route to engineer the network structure and biological activity of fibronectin fibrillar matrices in analogy with their physiological cell-mediated assembly. We identify specific surface chemistries that promote the cell-free formation of physiological-like fibronectin fibrils in a time- and concentration-dependent process. Our most recent and relevant results, reviewed in the chapter, demonstrate the role of this material-induced fibrillogenesis in cell adhesion, extracellular matrix organization and degradation, and cell differentiation.
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U2 - 10.1021/bk-2012-1120.ch022
DO - 10.1021/bk-2012-1120.ch022
M3 - Conference contribution
AN - SCOPUS:84904976634
SN - 9780841227965
T3 - ACS Symposium Series
SP - 471
EP - 496
BT - Proteins at Interfaces III State of the Art
PB - American Chemical Society
ER -