Mathematical modeling and sensitivity analysis of G1/S phase in the cell cycle including the DNA-damage signal transduction pathway

Kazunari Iwamoto, Yoshihiko Tashima, Hiroyuki Hamada, Yukihiro Eguchi, Masahiro Okamoto

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The cell cycle has checkpoint systems, which control G1/S, G2/M and G0/G1 phase transitions. When a normal cell suffers from DNA-damage, the signal transduction of DNA-damage causes the cell cycle arrest by using the checkpoint systems. Therefore, the elucidation of interaction between the signal transduction of DNA-damage and the checkpoint systems is an important problem. In this study, we constructed a novel mathematical model (proposed model) which integrated G1/S-checkpoint model with a signal transduction of DNA damage model and performed some numerical simulations. The proposed model realized some biological findings of G1/S phase with or without DNA-damage, which suggested that proposed model is biologically appropriate. Moreover, the results of sensitivity analysis of the proposed model indicated the predominant factors of G1/S phase and some factors concerned with the transformation of cells.

Original languageEnglish
Pages (from-to)109-117
Number of pages9
JournalBioSystems
Volume94
Issue number1-2
DOIs
Publication statusPublished - Oct 1 2008

Fingerprint

Signal transduction
Signal Transduction
G1 Phase
Cell Cycle
S Phase
Checkpoint
Mathematical Modeling
Sensitivity analysis
DNA Damage
Sensitivity Analysis
Pathway
DNA
Damage
Cells
Cell Cycle Checkpoints
Cell Cycle Resting Phase
Model
Phase Transition
Cell
Integrated Model

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Applied Mathematics

Cite this

Mathematical modeling and sensitivity analysis of G1/S phase in the cell cycle including the DNA-damage signal transduction pathway. / Iwamoto, Kazunari; Tashima, Yoshihiko; Hamada, Hiroyuki; Eguchi, Yukihiro; Okamoto, Masahiro.

In: BioSystems, Vol. 94, No. 1-2, 01.10.2008, p. 109-117.

Research output: Contribution to journalArticle

Iwamoto, Kazunari ; Tashima, Yoshihiko ; Hamada, Hiroyuki ; Eguchi, Yukihiro ; Okamoto, Masahiro. / Mathematical modeling and sensitivity analysis of G1/S phase in the cell cycle including the DNA-damage signal transduction pathway. In: BioSystems. 2008 ; Vol. 94, No. 1-2. pp. 109-117.
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