Matrix metalloproteinase-2 expression correlates with morphological and immunohistochemical epithelial characteristics in synovial sarcoma

T. Saito, Yoshinao Oda, A. Sakamoto, S. Tamiya, Y. Iwamoto, M. Tsuneyoshi

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Abstract

Aims: Synovial sarcoma is a unique mesenchymal tumour characterized by the presence of epithelial differentiation, although the mechanism involved in the epithelial morphology is still unclear. The aim of this study was to evaluate the function of matrix metalloproteinase-2 (MMP-2) in synovial sarcoma, in order to assess whether MMP-2 expression plays an important role in epithelial differentiation, or whether it contributes to a poor clinical outcome. Methods and results: Immunohistochemical stainings for MMP-2, cytokeratins (CKs) 7, 8, 18 and 19, and E-cadherin were performed for 58 (44 monophasic and 14 biphasic) cases of synovial sarcoma, and we compared the expression of these proteins with the histological and clinical findings. MMP-2 and E-cadherin expression was observed in 43 cases (74.1%) and in 18 cases (31.0%), respectively. Expression of these proteins was preferentially observed in the glandular components of biphasic tumours or the epithelioid areas of monophasic tumours. Statistically significant correlations were recognized between MMP-2 expression and E-cadherin expression of biphasic subtype. Moreover, there were statistically significant correlations between monophasic tumours with epithelioid areas and MMP-2 expression or E-cadherin expression. MMP-2 expression was correlated with epithelial differentiation as assessed by CK immunoreactivity. The expression of MMP-2 did not affect the overall survival rate in synovial sarcoma. Conclusions: MMP-2 expression seemed to have an important role to play in the epithelial differentiation of tumour cells in synovial sarcoma, through remodelling of the extracellular matrix and by changing the cytoskeletal interaction between the extracellular matrix and tumour cells.

Original languageEnglish
Pages (from-to)279-285
Number of pages7
JournalHistopathology
Volume40
Issue number3
DOIs
Publication statusPublished - Jan 1 2002

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Synovial Sarcoma
Matrix Metalloproteinase 2
Cadherins
Neoplasms
Extracellular Matrix
Keratin-8
Keratin-7
Keratin-19
Keratins
Cell Differentiation
Proteins
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology

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Matrix metalloproteinase-2 expression correlates with morphological and immunohistochemical epithelial characteristics in synovial sarcoma. / Saito, T.; Oda, Yoshinao; Sakamoto, A.; Tamiya, S.; Iwamoto, Y.; Tsuneyoshi, M.

In: Histopathology, Vol. 40, No. 3, 01.01.2002, p. 279-285.

Research output: Contribution to journalArticle

Saito, T. ; Oda, Yoshinao ; Sakamoto, A. ; Tamiya, S. ; Iwamoto, Y. ; Tsuneyoshi, M. / Matrix metalloproteinase-2 expression correlates with morphological and immunohistochemical epithelial characteristics in synovial sarcoma. In: Histopathology. 2002 ; Vol. 40, No. 3. pp. 279-285.
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