Matrix metalloproteinases are involved in mechanical stretch-induced activation of skeletal muscle satellite cells

Michiko Yamada, Ryuichi Tatsumi, Takashi Kikuiri, Shinpei Okamoto, Shinsuke Nonoshita, Wataru Mizunoya, Yoshihide Ikeuchi, Hiroaki Shimokawa, Kenji Sunagawa, Ronald E. Allen

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

When skeletal muscle is stretched or injured, myogenic satellite cells are activated to enter the cell cycle. This process depends on nitric oxide (NO) production, release of hepatocyte growth factor (HGF) from the extracellular matrix, and presentation of HGF to the c-met receptor. Experiments reported herein provide new evidence that matrix metalloproteinases (MMPs) are involved in the NO-dependent release of HGF in vitro. When rat satellite cells were treated with 10 ng/ml recombinant tissue inhibitor-1 of MMPs (TIMP-1) and subjected to treatments that induce activation in vitro, i.e., sodium nitroprusside (SNP) of an NO donor or mechanical cyclic stretch, the activation response was inhibited. In addition, conditioned medium generated by cultures treated with TIMP-1 plus SNP or mechanical stretch failed to activate cultured satellite cells and did not contain HGF. Moreover, NOx assay demonstrated that TIMP-1 does not impair NO synthase activity of stretched satellite cell cultures. Therefore, results from these experiments provide strong evidence that MMPs mediate HGF release from the matrix and that this step in the pathway is downstream from NO synthesis.

Original languageEnglish
Pages (from-to)313-319
Number of pages7
JournalMuscle and Nerve
Volume34
Issue number3
DOIs
Publication statusPublished - Sep 1 2006

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Skeletal Muscle Satellite Cells
Hepatocyte Growth Factor
Matrix Metalloproteinases
Tissue Inhibitor of Metalloproteinase-1
Nitric Oxide
Nitroprusside
Matrix Metalloproteinase 1
Nitric Oxide Donors
Conditioned Culture Medium
Nitric Oxide Synthase
Extracellular Matrix
Cultured Cells
Cell Cycle
Skeletal Muscle
Cell Culture Techniques

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

Cite this

Matrix metalloproteinases are involved in mechanical stretch-induced activation of skeletal muscle satellite cells. / Yamada, Michiko; Tatsumi, Ryuichi; Kikuiri, Takashi; Okamoto, Shinpei; Nonoshita, Shinsuke; Mizunoya, Wataru; Ikeuchi, Yoshihide; Shimokawa, Hiroaki; Sunagawa, Kenji; Allen, Ronald E.

In: Muscle and Nerve, Vol. 34, No. 3, 01.09.2006, p. 313-319.

Research output: Contribution to journalArticle

Yamada, M, Tatsumi, R, Kikuiri, T, Okamoto, S, Nonoshita, S, Mizunoya, W, Ikeuchi, Y, Shimokawa, H, Sunagawa, K & Allen, RE 2006, 'Matrix metalloproteinases are involved in mechanical stretch-induced activation of skeletal muscle satellite cells', Muscle and Nerve, vol. 34, no. 3, pp. 313-319. https://doi.org/10.1002/mus.20601
Yamada, Michiko ; Tatsumi, Ryuichi ; Kikuiri, Takashi ; Okamoto, Shinpei ; Nonoshita, Shinsuke ; Mizunoya, Wataru ; Ikeuchi, Yoshihide ; Shimokawa, Hiroaki ; Sunagawa, Kenji ; Allen, Ronald E. / Matrix metalloproteinases are involved in mechanical stretch-induced activation of skeletal muscle satellite cells. In: Muscle and Nerve. 2006 ; Vol. 34, No. 3. pp. 313-319.
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