Measles virus hemagglutinin: Structural insights into cell entry and measles vaccine

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

Measles is one of the most contagious viral diseases, and remains a major cause of childhood morbidity and mortality worldwide. The measles virus (MV), a member of the family Paramyxoviridae, enters cells through a cellular receptor, the signaling lymphocyte activation molecule (SLAM), CD46 or nectin-4. Entry is mediated by two MV envelope glyco-proteins, the hemagglutinin (H) and the fusion (F) protein. The H protein mediates receptor attachment, while the F protein causes membrane fusion. The interaction between the H and F proteins is essential to initiate the cell entry process. Recently determined crystal structures of the MV-H protein unbound and bound to SLAM or CD46 have provided insights into paramyxovirus entry and the effectiveness of measles vaccine.

Original languageEnglish
JournalFrontiers in Microbiology
Volume2
Issue numberDEC
DOIs
Publication statusPublished - Jan 1 2011

Fingerprint

Measles Vaccine
Measles virus
Hemagglutinins
Lymphocyte Activation
Paramyxoviridae
Membrane Fusion Proteins
Viral Envelope Proteins
Proteins
Measles
Virus Diseases
Morbidity
Mortality

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)

Cite this

Measles virus hemagglutinin : Structural insights into cell entry and measles vaccine. / Hashiguchi, Takao; Maenaka, Katsumi; Yanagi, Yusuke.

In: Frontiers in Microbiology, Vol. 2, No. DEC, 01.01.2011.

Research output: Contribution to journalReview article

@article{ec9bd24189fa4edc818130d805ba287c,
title = "Measles virus hemagglutinin: Structural insights into cell entry and measles vaccine",
abstract = "Measles is one of the most contagious viral diseases, and remains a major cause of childhood morbidity and mortality worldwide. The measles virus (MV), a member of the family Paramyxoviridae, enters cells through a cellular receptor, the signaling lymphocyte activation molecule (SLAM), CD46 or nectin-4. Entry is mediated by two MV envelope glyco-proteins, the hemagglutinin (H) and the fusion (F) protein. The H protein mediates receptor attachment, while the F protein causes membrane fusion. The interaction between the H and F proteins is essential to initiate the cell entry process. Recently determined crystal structures of the MV-H protein unbound and bound to SLAM or CD46 have provided insights into paramyxovirus entry and the effectiveness of measles vaccine.",
author = "Takao Hashiguchi and Katsumi Maenaka and Yusuke Yanagi",
year = "2011",
month = "1",
day = "1",
doi = "10.3389/fmicb.2011.00247",
language = "English",
volume = "2",
journal = "Frontiers in Microbiology",
issn = "1664-302X",
publisher = "Frontiers Media S. A.",
number = "DEC",

}

TY - JOUR

T1 - Measles virus hemagglutinin

T2 - Structural insights into cell entry and measles vaccine

AU - Hashiguchi, Takao

AU - Maenaka, Katsumi

AU - Yanagi, Yusuke

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Measles is one of the most contagious viral diseases, and remains a major cause of childhood morbidity and mortality worldwide. The measles virus (MV), a member of the family Paramyxoviridae, enters cells through a cellular receptor, the signaling lymphocyte activation molecule (SLAM), CD46 or nectin-4. Entry is mediated by two MV envelope glyco-proteins, the hemagglutinin (H) and the fusion (F) protein. The H protein mediates receptor attachment, while the F protein causes membrane fusion. The interaction between the H and F proteins is essential to initiate the cell entry process. Recently determined crystal structures of the MV-H protein unbound and bound to SLAM or CD46 have provided insights into paramyxovirus entry and the effectiveness of measles vaccine.

AB - Measles is one of the most contagious viral diseases, and remains a major cause of childhood morbidity and mortality worldwide. The measles virus (MV), a member of the family Paramyxoviridae, enters cells through a cellular receptor, the signaling lymphocyte activation molecule (SLAM), CD46 or nectin-4. Entry is mediated by two MV envelope glyco-proteins, the hemagglutinin (H) and the fusion (F) protein. The H protein mediates receptor attachment, while the F protein causes membrane fusion. The interaction between the H and F proteins is essential to initiate the cell entry process. Recently determined crystal structures of the MV-H protein unbound and bound to SLAM or CD46 have provided insights into paramyxovirus entry and the effectiveness of measles vaccine.

UR - http://www.scopus.com/inward/record.url?scp=84868140783&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84868140783&partnerID=8YFLogxK

U2 - 10.3389/fmicb.2011.00247

DO - 10.3389/fmicb.2011.00247

M3 - Review article

C2 - 22319511

AN - SCOPUS:84868140783

VL - 2

JO - Frontiers in Microbiology

JF - Frontiers in Microbiology

SN - 1664-302X

IS - DEC

ER -