Measles virus hemagglutinin: Structural insights into cell entry and measles vaccine

Takao Hashiguchi, Katsumi Maenaka, Yusuke Yanagi

Research output: Contribution to journalReview articlepeer-review

38 Citations (Scopus)


Measles is one of the most contagious viral diseases, and remains a major cause of childhood morbidity and mortality worldwide. The measles virus (MV), a member of the family Paramyxoviridae, enters cells through a cellular receptor, the signaling lymphocyte activation molecule (SLAM), CD46 or nectin-4. Entry is mediated by two MV envelope glyco-proteins, the hemagglutinin (H) and the fusion (F) protein. The H protein mediates receptor attachment, while the F protein causes membrane fusion. The interaction between the H and F proteins is essential to initiate the cell entry process. Recently determined crystal structures of the MV-H protein unbound and bound to SLAM or CD46 have provided insights into paramyxovirus entry and the effectiveness of measles vaccine.

Original languageEnglish
JournalFrontiers in Microbiology
Issue numberDEC
Publication statusPublished - 2011

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)


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