TY - JOUR
T1 - Measles virus hemagglutinin
T2 - Structural insights into cell entry and measles vaccine
AU - Hashiguchi, Takao
AU - Maenaka, Katsumi
AU - Yanagi, Yusuke
PY - 2011
Y1 - 2011
N2 - Measles is one of the most contagious viral diseases, and remains a major cause of childhood morbidity and mortality worldwide. The measles virus (MV), a member of the family Paramyxoviridae, enters cells through a cellular receptor, the signaling lymphocyte activation molecule (SLAM), CD46 or nectin-4. Entry is mediated by two MV envelope glyco-proteins, the hemagglutinin (H) and the fusion (F) protein. The H protein mediates receptor attachment, while the F protein causes membrane fusion. The interaction between the H and F proteins is essential to initiate the cell entry process. Recently determined crystal structures of the MV-H protein unbound and bound to SLAM or CD46 have provided insights into paramyxovirus entry and the effectiveness of measles vaccine.
AB - Measles is one of the most contagious viral diseases, and remains a major cause of childhood morbidity and mortality worldwide. The measles virus (MV), a member of the family Paramyxoviridae, enters cells through a cellular receptor, the signaling lymphocyte activation molecule (SLAM), CD46 or nectin-4. Entry is mediated by two MV envelope glyco-proteins, the hemagglutinin (H) and the fusion (F) protein. The H protein mediates receptor attachment, while the F protein causes membrane fusion. The interaction between the H and F proteins is essential to initiate the cell entry process. Recently determined crystal structures of the MV-H protein unbound and bound to SLAM or CD46 have provided insights into paramyxovirus entry and the effectiveness of measles vaccine.
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U2 - 10.3389/fmicb.2011.00247
DO - 10.3389/fmicb.2011.00247
M3 - Review article
C2 - 22319511
AN - SCOPUS:84868140783
VL - 2
JO - Frontiers in Microbiology
JF - Frontiers in Microbiology
SN - 1664-302X
IS - DEC
ER -