Measles virus receptors

Y. Yanagi, M. Takeda, S. Ohno, T. Hashiguchi

Research output: Chapter in Book/Report/Conference proceedingChapter

67 Citations (Scopus)

Abstract

Measles virus (MV) has two envelope glycoproteins, the hemagglutinin (H) and fusion protein, which are responsible for attachment and membrane fusion, respectively. Signaling lymphocyte activation molecule (SLAM, also called CD150), a membrane glycoprotein expressed on immune cells, acts as the principal cellular receptor for MV, accounting for its lymphotropism and immunosuppressive nature. MV also infects polarized epithelial cells via an as yet unknown receptor molecule, thereby presumably facilitating transmission via aerosol droplets. Vaccine and laboratory-adapted strains of MV use ubiquitously expressed CD46 as an alternate receptor through amino acid substitutions in the H protein. The crystal structure of the H protein indicates that the putative binding sites for SLAM, CD46, and the epithelial cell receptor are strategically located in different positions of the H protein. Other molecules have also been implicated in MV infection, although their relevance remains to be determined. The identification of MV receptors has advanced our understanding of MV tropism and pathogenesis.

Original languageEnglish
Title of host publicationMeasles
Subtitle of host publicationHistory and Basic Biology
EditorsDiane Griffin, Michael Oldstone
Pages13-30
Number of pages18
DOIs
Publication statusPublished - 2009

Publication series

NameCurrent Topics in Microbiology and Immunology
Volume329
ISSN (Print)0070-217X

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

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