Measurement method for hydroxylated polychlorinated biphenyls in the blood of Yusho patients by liquid chromatography-electrospray tandem mass spectrometry.

Kazuhiro Tobiishi, Takashi Todaka, Hironori Hirakawa, Tsuguhide Hori, Jumboku Kajiwara, Teruaki Hirata, Takao Iida, Uchi Hiroshi, Masutaka Furue

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7 Citations (Scopus)

Abstract

Hydroxylated polychlorinated biphenyls (OH-PCBs) are formed as major metabolites of PCBs by cytochrome P450 enzyme-mediated oxidation. It has been reported that their total concentration in serum samples of Yusho patients ranged from 390 to 1300 pg/g. We developed a measurement method for OH-PCBs in blood samples by LC/MS/MS. This method is effective at determining the concentrations of PCDDs, PCDFs, Co-PCBs and OH-PCBs from the same sample without special treatment of the sample. The concentration of OH-PCBs in the blood of Yusho patients was examined using this method. The major OH-PCB metabolites were 4-OH-CB187 (54-906 pg/g-wet), 4-OH-CB146 + 3-OH-CB153 (32-527 pg/g-wet), 4-OH-CB109 (ND-229 pg/g-wet) and 4'-OH-CB172 (ND-143 pg/g-wet). The total OH-PCBs ranged from 95 to 1740 pg/g-wet.

Original languageEnglish
Pages (from-to)153-158
Number of pages6
JournalFukuoka Acta Medica
Volume102
Issue number4
Publication statusPublished - Apr 2011

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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