生体分子モーター・キネシンの"散逸"を計測する

Translated title of the contribution: Measuring Dissipation of Molecular Motor Kinesin

有賀 隆行, 富重 道雄, 水野 大介

Research output: Contribution to journalArticlepeer-review

Abstract

<p>Molecular motors are nonequilibrium open systems that convert chemical energy to mechanical work. The nonequilibrium energetics of single molecule kinesin were investigated by measuring the motion of an attached probe particle and its response to external forces with optical tweezers. The sum of the heat dissipation estimated from the violation of the fluctuation-response relation and the output power was inconsistent with the input free energy rate, indicating that large internal dissipation exists. Here we introduce the theoretical basis of the dissipation measurement and our recent experimental results, discussing the physiological implications of the hidden dissipation in the kinesin motor.</p>
Translated title of the contributionMeasuring Dissipation of Molecular Motor Kinesin
Original languageJapanese
Pages (from-to)300-304
Number of pages5
Journal生物物理
Volume59
Issue number6
DOIs
Publication statusPublished - 2019

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