Meat, fish and fat intake in relation to subsite-specific risk of colorectal cancer: The Fukuoka Colorectal Cancer Study

Yasumi Kimura, Suminori Kono, Kengo Toyomura, Jun Nagano, Tetsuya Mizoue, Malcolm A. Moore, Ryuichi Mibu, Masao Tanaka, Yoshihiro Kakeji, Yoshihiko Maehara, Takeshi Okamura, Koji Ikejiri, Kitaroh Futami, Yohichi Yasunami, Takafumi Maekawa, Kenji Takenaka, Hitoshi Ichimiya, Nobutoshi Imaizumi

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

High intake of red meat has been associated with increased risk of colorectal cancer in Western countries. There has been much interest in the role of n-3 polyunsaturated fatty acids (PUFA) in colorectal cancer prevention, but epidemiological findings are limited and inconsistent. The objective of our study was to examine associations of meat, fish and fat intake with risk of colorectal cancer, paying particular attention to the subsite within the colorectum. Data were from the Fukuoka Colorectal Cancer Study, a population-based case-control study, covering 782 cases and 793 controls. Diet was assessed by interview, using newly developed personal-computer software for registering semiquantitative food frequencies. The intake of beef/pork, processed meat, total fat, saturated fat or n-6 PUFA showed no clear association with the overall or subsite-specific risk of colorectal cancer. There was an almost significant inverse association between n-3 PUFA and the risk of colorectal cancer; the covariate-adjusted odds ratio for the highest (median 3.94 g/day) versus lowest (median 1.99 g/day) quintile of energy-adjusted intake was 0.74 (95% confidence interval 0.52-1.06, trend P = 0.050). The consumption of fish and fish products was similarly inversely related to the risk although the association was not statistically significant. These associations were more evident for distal colon cancer; adjusted odds ratio for the highest versus lowest quintile of n-3 PUFA intake was 0.56 (95% confidence interval 0.34-0.92, trend P = 0.02). Our findings do not support the hypothesis that consumption of red meat increases colorectal cancer risk but do suggest that high intake of fish may decrease the risk, particularly of distal colon cancer.

Original languageEnglish
Pages (from-to)590-597
Number of pages8
JournalCancer Science
Volume98
Issue number4
DOIs
Publication statusPublished - Apr 1 2007

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Meat
Colorectal Neoplasms
Fishes
Fats
Omega-3 Fatty Acids
Colonic Neoplasms
Odds Ratio
Confidence Intervals
Fish Products
Microcomputers
Energy Intake
Unsaturated Fatty Acids
Case-Control Studies
Software
Interviews
Diet
Food
Red Meat
Population

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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Meat, fish and fat intake in relation to subsite-specific risk of colorectal cancer : The Fukuoka Colorectal Cancer Study. / Kimura, Yasumi; Kono, Suminori; Toyomura, Kengo; Nagano, Jun; Mizoue, Tetsuya; Moore, Malcolm A.; Mibu, Ryuichi; Tanaka, Masao; Kakeji, Yoshihiro; Maehara, Yoshihiko; Okamura, Takeshi; Ikejiri, Koji; Futami, Kitaroh; Yasunami, Yohichi; Maekawa, Takafumi; Takenaka, Kenji; Ichimiya, Hitoshi; Imaizumi, Nobutoshi.

In: Cancer Science, Vol. 98, No. 4, 01.04.2007, p. 590-597.

Research output: Contribution to journalArticle

Kimura, Y, Kono, S, Toyomura, K, Nagano, J, Mizoue, T, Moore, MA, Mibu, R, Tanaka, M, Kakeji, Y, Maehara, Y, Okamura, T, Ikejiri, K, Futami, K, Yasunami, Y, Maekawa, T, Takenaka, K, Ichimiya, H & Imaizumi, N 2007, 'Meat, fish and fat intake in relation to subsite-specific risk of colorectal cancer: The Fukuoka Colorectal Cancer Study', Cancer Science, vol. 98, no. 4, pp. 590-597. https://doi.org/10.1111/j.1349-7006.2007.00425.x
Kimura, Yasumi ; Kono, Suminori ; Toyomura, Kengo ; Nagano, Jun ; Mizoue, Tetsuya ; Moore, Malcolm A. ; Mibu, Ryuichi ; Tanaka, Masao ; Kakeji, Yoshihiro ; Maehara, Yoshihiko ; Okamura, Takeshi ; Ikejiri, Koji ; Futami, Kitaroh ; Yasunami, Yohichi ; Maekawa, Takafumi ; Takenaka, Kenji ; Ichimiya, Hitoshi ; Imaizumi, Nobutoshi. / Meat, fish and fat intake in relation to subsite-specific risk of colorectal cancer : The Fukuoka Colorectal Cancer Study. In: Cancer Science. 2007 ; Vol. 98, No. 4. pp. 590-597.
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