TY - JOUR
T1 - Mechanical behavior and cell response of PCL coated α-TCP foam for cancellous-type bone replacement
AU - Bang, Le Thi
AU - Tsuru, Kanji
AU - Munar, Melvin
AU - Ishikawa, Kunio
AU - Othman, Radzali
N1 - Funding Information:
This study was supported in part by a Grant-in-Aid for Scientific Research from the Japan Science and Technology Agency, Ministry of Education, Sports, Culture, Science and Technology, Japan , and by the AUN/SEED-Net project under the Japan International Cooperation Agency (JICA) .
PY - 2013/7
Y1 - 2013/7
N2 - The mechanical behavior and cell responses of poly (ε-carpolactone) (PCL) coated α-tricalcium phosphate (α-TCP) foam were studied as an initial step for the fabrication of a cancellous-type artificial bone replacement. The α-TCP foam was obtained from sintering CaCO3 and CaHPO4·2H2O at 1500 °C. It was then coated with PCL and its three dimensional fully-interconnected porous structure was found to be maintained. The coated α-TCP samples exhibited high porosity (80-85%) with large pore size (500-700 μm) that mimic the cancellous bone structure. The PCL content of the coating layer increased from 9.3±0.4 wt% to 19.0±1.3 wt% when coated with 5 wt% to 15 wt% PCL. The compressive strength improved significantly upon PCL coating. The compressive strength of α-TCP foam, 30±10 kPa, increased to 750±20 kPa when coated with 15 wt% of PCL solution. The in vitro biological evaluations indicated that MC3T3-E1 cells adhered and proliferated well on both the α-TCP and the PCL coated α-TCP foams. It was concluded that α-TCP foam upon coating with bioresorable PCL is of good potential to fabricate cancellous-type artificial bone replacement.
AB - The mechanical behavior and cell responses of poly (ε-carpolactone) (PCL) coated α-tricalcium phosphate (α-TCP) foam were studied as an initial step for the fabrication of a cancellous-type artificial bone replacement. The α-TCP foam was obtained from sintering CaCO3 and CaHPO4·2H2O at 1500 °C. It was then coated with PCL and its three dimensional fully-interconnected porous structure was found to be maintained. The coated α-TCP samples exhibited high porosity (80-85%) with large pore size (500-700 μm) that mimic the cancellous bone structure. The PCL content of the coating layer increased from 9.3±0.4 wt% to 19.0±1.3 wt% when coated with 5 wt% to 15 wt% PCL. The compressive strength improved significantly upon PCL coating. The compressive strength of α-TCP foam, 30±10 kPa, increased to 750±20 kPa when coated with 15 wt% of PCL solution. The in vitro biological evaluations indicated that MC3T3-E1 cells adhered and proliferated well on both the α-TCP and the PCL coated α-TCP foams. It was concluded that α-TCP foam upon coating with bioresorable PCL is of good potential to fabricate cancellous-type artificial bone replacement.
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U2 - 10.1016/j.ceramint.2012.12.079
DO - 10.1016/j.ceramint.2012.12.079
M3 - Article
AN - SCOPUS:84875752682
VL - 39
SP - 5631
EP - 5637
JO - Ceramics International
JF - Ceramics International
SN - 0272-8842
IS - 5
ER -