Mechanical characterization of a single cell using v-beam interface employed on-chip probe

Shinya Sakuma, Keitaro Ito, Makoto Kaneko, Fumihito Arai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We present an on-chip mechanical characterization of a single cell using a robot integrated microfluidic chip (robochip). We integrate a pair of on-chip probe and force sensor into microchannels, and measure the cellular mechanical properties from information of cellular reaction force when they are deformed. The key for this measurement method is how to actuate the on-chip probe in closed space of a microfluidic chip. We utilize a V-beam interface for actuation of the on-chip probe. By utilizing piezoelectric actuators as external high-speed actuator, we can actuate the on-chip probe with high-speed. Finally, we show the cell mechanical characterization using mouse oocyte.

Original languageEnglish
Title of host publicationMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages1383-1385
Number of pages3
ISBN (Electronic)9780979806483
Publication statusPublished - 2015
Externally publishedYes
Event19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of
Duration: Oct 25 2015Oct 29 2015

Publication series

NameMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Other

Other19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
Country/TerritoryKorea, Republic of
CityGyeongju
Period10/25/1510/29/15

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

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