Mechanical oscillation of dynamic microtubule rings

Masaki Ito, Arif Md Rashedul Kabir, Md Sirajul Islam, Daisuke Inoue, Shoki Wada, Kazuki Sada, Akihiko Konagaya, Akira Kakugo

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4 Citations (Scopus)

Abstract

Mechanical oscillation is a ubiquitous phenomenon observed in living systems, which emerges from a wide range of well-organized self-assembled structures, and plays important roles in many biological processes. Although considerable efforts have been devoted to demonstrate the mechanical oscillation of organized structures produced through self-assembly in vitro, it has rarely been documented. Here we report the mechanical oscillation of ring-shaped structures, composed of multiple microtubule (MT) filaments, obtained through energy dissipative self-assembly of MT filaments at an air-buffer interface. The MT rings exhibit autonomous oscillation manifested through periodic changes in the size and shape. We propose the oscillation of the MT rings is attributed to mechanical feedback arising from accumulated stress induced by the driving force of the motor protein system. This work might offer new insights to our current understanding on the mechanical feedback driven oscillation of organized structures and its effect on dynamic processes in living systems.

Original languageEnglish
Pages (from-to)69149-69155
Number of pages7
JournalRSC Advances
Volume6
Issue number73
DOIs
Publication statusPublished - Jan 1 2016
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Ito, M., Rashedul Kabir, A. M., Islam, M. S., Inoue, D., Wada, S., Sada, K., ... Kakugo, A. (2016). Mechanical oscillation of dynamic microtubule rings. RSC Advances, 6(73), 69149-69155. https://doi.org/10.1039/c6ra16613j