Mechanical responses of a compliant electrospun poly(L-lactide-co-ε- caprolactone) small-diameter vascular graft

Hiroyuki Inoguchi, Il Keun Kwon, Eiko Inoue, Keiichi Takamizawa, Yoshihiko Maehara, Takehisa Matsuda

Research output: Contribution to journalArticlepeer-review

136 Citations (Scopus)

Abstract

To design a "mechano-active" small-diameter artificial vascular graft, a tubular scaffold made of elastomeric poly(l-lactide-co-ε- caprolactone) fabrics at different wall thicknesses was fabricated using an electrospinning (ELSP) technique. The wall thickness of the fabricated tube (inner diameter; approximately 2.3-2.5 mm and wall thickness; 50-340 μm) increased proportionally with ELSP time. The wall thickness dependence of mechanical responses including intraluminal pressure-induced inflation was determined under static and dynamic flow conditions. From the compliance-related parameters (stiffness parameter and diameter compliance) measured under static condition, the smaller the wall thickness, the more compliant the tube. Under dynamic flow condition (1 Hz, maximal/minimal pressure of 90 mmHg/45 mmHg) produced by a custom-designed arterial circulatory system, strain, defined as the relative increase in diameter per pulse, increased with the decrease in wall thickness, which approached that of a native artery. Thus, a mechano-active scaffold that pulsates synchronously by responding to pulsatile flow was prepared using elastomeric PLCL as a base material and an ELSP technique.

Original languageEnglish
Pages (from-to)1470-1478
Number of pages9
JournalBiomaterials
Volume27
Issue number8
DOIs
Publication statusPublished - Mar 2006

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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