Mechanical Stimulation-Induced Orientation of Gliding Microtubules in Confined Microwells

Daisuke Inoue, Arif Md Rashedul Kabir, Kiyotaka Tokuraku, Kazuki Sada, Akira Kakugo

Research output: Contribution to journalArticle

Abstract

Biomolecular motors are the smallest natural machines that can convert chemical energy into mechanical work with much higher energy efficiencies compared to man-made machineries. Nowadays, reconstructed biomolecular motors, such as microtubules–kinesin, are successfully utilized for nanotechnological applications, e.g., in nanotransportation, parallel computation, molecular robotics, and so on. However, stochastic nature of their motion poses a limitation to their applications, which is difficult to control particularly under spatial constraints. In this work, top-down and bottom-up approaches are combined to address this problem in a gliding assay of microtubules. Through mechanical stimulation of the motile microtubule filaments, parallelization of the filaments is demonstrated concurrently in hundreds of microwells. The orientation of plenty of motile microtubules in confined space should further accelerate nanotechnological applications of biomolecular motors.

Original languageEnglish
JournalAdvanced Materials Interfaces
DOIs
Publication statusAccepted/In press - Jan 1 2020

All Science Journal Classification (ASJC) codes

  • Mechanics of Materials
  • Mechanical Engineering

Fingerprint Dive into the research topics of 'Mechanical Stimulation-Induced Orientation of Gliding Microtubules in Confined Microwells'. Together they form a unique fingerprint.

  • Cite this