Mechanical Stimulation-Induced Orientation of Gliding Microtubules in Confined Microwells

Daisuke Inoue, Arif Md Rashedul Kabir, Kiyotaka Tokuraku, Kazuki Sada, Akira Kakugo

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Biomolecular motors are the smallest natural machines that can convert chemical energy into mechanical work with much higher energy efficiencies compared to man-made machineries. Nowadays, reconstructed biomolecular motors, such as microtubules–kinesin, are successfully utilized for nanotechnological applications, e.g., in nanotransportation, parallel computation, molecular robotics, and so on. However, stochastic nature of their motion poses a limitation to their applications, which is difficult to control particularly under spatial constraints. In this work, top-down and bottom-up approaches are combined to address this problem in a gliding assay of microtubules. Through mechanical stimulation of the motile microtubule filaments, parallelization of the filaments is demonstrated concurrently in hundreds of microwells. The orientation of plenty of motile microtubules in confined space should further accelerate nanotechnological applications of biomolecular motors.

Original languageEnglish
Article number1902013
JournalAdvanced Materials Interfaces
Volume7
Issue number13
DOIs
Publication statusPublished - Jul 1 2020

All Science Journal Classification (ASJC) codes

  • Mechanics of Materials
  • Mechanical Engineering

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