Mechanism of apatite formation on a sodium silicate glass in a simulated body fluid

Satoshi Hayakawa, Kanji Tsuru, Chikara Ohtsuki, Akiyoshi Osaka

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

29Si and 31P magic-angle-spinning nuclear magnetic resonance (MAS-NMR) spectra were used to analyze 20Na2O·80SiO2 glass particles before and after soaking in a simulated body fluid (SBF; Kokubo solution, pH 7.4) for various periods (up to 14 d). The structure of the bulk glass and the glass surface, as well as the chemical states of the calcium phosphates adsorbed on the glass surface, were examined. The bulk glass before soaking in the SBF showed two 29Si MAS-NMR resonances, at -100 and -110 ppm, which were attributable to Si(OSi)3ONa and Si(OSi)4 units, respectively. A new -105 ppm peak, which was due to Si(OSi)3OH units, appeared after soaking in the SBF and grew as the soaking period increased. Thus, in the SBF, the glass network was degraded and hydrolyzed; that is, dissolution of the Na+ ions from the glass network and the formation of Si-O- groups occurred. After soaking for 1 d, a 31P MAS-NMR resonance peak of orthophosphate (PO4 3-) ions that were deposited on the glass surface appeared at approx. 3.0 ppm and grew as the soaking period increased. The chemical shift shows that the local structural environment of phosphorus atoms and ions was very similar to that of hydroxyapatite or rabbit cortical bone. Inductively coupled plasma atomic emission spectroscopic analysis confirmed the adsorption of calcium phosphates on the glasses and the close relationship between the dissolution of the NaPLU ions and the precipitation of the calcium phosphates. It was concluded that the layer of hydrated silica gel, which was composed of Si(OSi)3O- units, provided the negatively charged sites that induced or promoted the precipitation of calcium phosphates, which led to apatite nucleation and crystallization.

Original languageEnglish
Pages (from-to)2155-2160
Number of pages6
JournalJournal of the American Ceramic Society
Volume82
Issue number8
Publication statusPublished - 1999
Externally publishedYes

Fingerprint

Apatites
Body fluids
Apatite
Silicates
Sodium
Calcium Phosphates
Glass
Calcium phosphate
Magic angle spinning
Ions
Nuclear magnetic resonance
Dissolution
Silicic Acid
sodium silicate
Spectroscopic analysis
Chemical shift
Silica gel
Inductively coupled plasma
Durapatite
Crystallization

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites

Cite this

Mechanism of apatite formation on a sodium silicate glass in a simulated body fluid. / Hayakawa, Satoshi; Tsuru, Kanji; Ohtsuki, Chikara; Osaka, Akiyoshi.

In: Journal of the American Ceramic Society, Vol. 82, No. 8, 1999, p. 2155-2160.

Research output: Contribution to journalArticle

Hayakawa, S, Tsuru, K, Ohtsuki, C & Osaka, A 1999, 'Mechanism of apatite formation on a sodium silicate glass in a simulated body fluid', Journal of the American Ceramic Society, vol. 82, no. 8, pp. 2155-2160.
Hayakawa, Satoshi ; Tsuru, Kanji ; Ohtsuki, Chikara ; Osaka, Akiyoshi. / Mechanism of apatite formation on a sodium silicate glass in a simulated body fluid. In: Journal of the American Ceramic Society. 1999 ; Vol. 82, No. 8. pp. 2155-2160.
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AU - Tsuru, Kanji

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AU - Osaka, Akiyoshi

PY - 1999

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N2 - 29Si and 31P magic-angle-spinning nuclear magnetic resonance (MAS-NMR) spectra were used to analyze 20Na2O·80SiO2 glass particles before and after soaking in a simulated body fluid (SBF; Kokubo solution, pH 7.4) for various periods (up to 14 d). The structure of the bulk glass and the glass surface, as well as the chemical states of the calcium phosphates adsorbed on the glass surface, were examined. The bulk glass before soaking in the SBF showed two 29Si MAS-NMR resonances, at -100 and -110 ppm, which were attributable to Si(OSi)3ONa and Si(OSi)4 units, respectively. A new -105 ppm peak, which was due to Si(OSi)3OH units, appeared after soaking in the SBF and grew as the soaking period increased. Thus, in the SBF, the glass network was degraded and hydrolyzed; that is, dissolution of the Na+ ions from the glass network and the formation of Si-O- groups occurred. After soaking for 1 d, a 31P MAS-NMR resonance peak of orthophosphate (PO4 3-) ions that were deposited on the glass surface appeared at approx. 3.0 ppm and grew as the soaking period increased. The chemical shift shows that the local structural environment of phosphorus atoms and ions was very similar to that of hydroxyapatite or rabbit cortical bone. Inductively coupled plasma atomic emission spectroscopic analysis confirmed the adsorption of calcium phosphates on the glasses and the close relationship between the dissolution of the NaPLU ions and the precipitation of the calcium phosphates. It was concluded that the layer of hydrated silica gel, which was composed of Si(OSi)3O- units, provided the negatively charged sites that induced or promoted the precipitation of calcium phosphates, which led to apatite nucleation and crystallization.

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