Mechanism of demyelination in the guinea pig - Separate sensitization with encephalitogenic myelin basic protein and nonencephalitogenic brain components

Bernard F. Driscoll, Junichi Kira, Marian W. Kies, Ellsworth C. Alvord

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Experimental allergic encephalomyelitis (EAE), accompanied by demyelinating central nervous system (CNS) lesions, can be induced in guinea pigs sensitized with whole guinea pig CNS tissue, but not in animals sensitized with purified myelin basic protein (BP). This type of chronic demyelinating EAE is presumably a result of a combination of a cell-mediated immune response to the encephalitogenic BP and a separate response to other nonencephalitogenic CNS antigens. We report here that demyelinating EAE can be induced when separate sensitizations are used to induce a cell-mediated response to BP and a second immune response to nonencephalitogenic CNS antigens. Animals sensitized in separate sites with guinea pig BP and whole chicken brain develop CNS demyelinating lesions. Animals sensitized only to BP or chicken brain do not develop demyelination. The antigen(s) responsible for demyelination are found in the myelin fraction of chicken brain.

Original languageEnglish
Pages (from-to)11-22
Number of pages12
JournalNeurochemical Pathology
Volume4
Issue number1
DOIs
Publication statusPublished - Feb 1 1986
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Mechanism of demyelination in the guinea pig - Separate sensitization with encephalitogenic myelin basic protein and nonencephalitogenic brain components'. Together they form a unique fingerprint.

Cite this