Mechanism of inactivation of oral cancer cells irradiated by active oxygen species from DBD plasma

Keisuke Mine, Yukie Miyamaru, Nobuya Hayashi, Reona Aijima, Yoshio Yamashita

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    Inactivation effect of active oxygen species generated by torch-type dielectric barrier discharge on oral cancer cells was investigated. In order to irradiate cells directly with active oxygen species, the culture medium is removed from a culture dish. Activation of c-jun N-terminal kinase (INK), p38 proteins, and p53 enzymes in oral cancer cells by active oxygen species indicated that the cells suffered apoptosis. Selective inactivation between cancer and normal cells was obtained by irradiation with active oxygen species for a relatively short period of less than 60 sec.

    Original languageEnglish
    Pages (from-to)201-214
    Number of pages14
    JournalPlasma Medicine
    Volume7
    Issue number3
    DOIs
    Publication statusPublished - Jan 1 2017

    Fingerprint

    deactivation
    cancer
    Cells
    Plasmas
    Oxygen
    oxygen
    cells
    culture media
    torches
    parabolic reflectors
    apoptosis
    Cell death
    enzymes
    Enzymes
    Chemical activation
    Irradiation
    activation
    proteins
    Proteins
    irradiation

    All Science Journal Classification (ASJC) codes

    • Biomedical Engineering
    • Physics and Astronomy(all)

    Cite this

    Mechanism of inactivation of oral cancer cells irradiated by active oxygen species from DBD plasma. / Mine, Keisuke; Miyamaru, Yukie; Hayashi, Nobuya; Aijima, Reona; Yamashita, Yoshio.

    In: Plasma Medicine, Vol. 7, No. 3, 01.01.2017, p. 201-214.

    Research output: Contribution to journalArticle

    Mine, Keisuke ; Miyamaru, Yukie ; Hayashi, Nobuya ; Aijima, Reona ; Yamashita, Yoshio. / Mechanism of inactivation of oral cancer cells irradiated by active oxygen species from DBD plasma. In: Plasma Medicine. 2017 ; Vol. 7, No. 3. pp. 201-214.
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