Abstract
Mitochondrial morphology changes continuously through fusion, fission, and movement in response to different physiologic requirements of the cell. These highly dynamic behaviors are crucial for cell life and death, and are linked to development, apoptosis, and maintenance of cellular homeostasis; as well as to pathologies, such as neurologic and metabolic diseases. A large number of novel proteins involved in regulating mitochondrial dynamics have been discovered in the past decade. Large GTPase family proteins and their regulators control mitochondrial dynamics. Here, we summarize current knowledge about the molecular machineries regulating mitochondrial fusion/fission and the role of mitochondrial dynamics in cell pathophysiology.
| Original language | English |
|---|---|
| Title of host publication | Organizational Cell Biology |
| Publisher | Elsevier Inc. |
| Pages | 279-292 |
| Number of pages | 14 |
| Volume | 2 |
| ISBN (Electronic) | 9780123944474 |
| ISBN (Print) | 9780123947963 |
| DOIs | |
| Publication status | Published - Jan 1 2016 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
Cite this
Mechanisms and Functions of Mitochondrial Dynamics. / Mihara, K.; Otera, H.
Organizational Cell Biology. Vol. 2 Elsevier Inc., 2016. p. 279-292.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Mechanisms and Functions of Mitochondrial Dynamics
AU - Mihara, K.
AU - Otera, H.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Mitochondrial morphology changes continuously through fusion, fission, and movement in response to different physiologic requirements of the cell. These highly dynamic behaviors are crucial for cell life and death, and are linked to development, apoptosis, and maintenance of cellular homeostasis; as well as to pathologies, such as neurologic and metabolic diseases. A large number of novel proteins involved in regulating mitochondrial dynamics have been discovered in the past decade. Large GTPase family proteins and their regulators control mitochondrial dynamics. Here, we summarize current knowledge about the molecular machineries regulating mitochondrial fusion/fission and the role of mitochondrial dynamics in cell pathophysiology.
AB - Mitochondrial morphology changes continuously through fusion, fission, and movement in response to different physiologic requirements of the cell. These highly dynamic behaviors are crucial for cell life and death, and are linked to development, apoptosis, and maintenance of cellular homeostasis; as well as to pathologies, such as neurologic and metabolic diseases. A large number of novel proteins involved in regulating mitochondrial dynamics have been discovered in the past decade. Large GTPase family proteins and their regulators control mitochondrial dynamics. Here, we summarize current knowledge about the molecular machineries regulating mitochondrial fusion/fission and the role of mitochondrial dynamics in cell pathophysiology.
UR - http://www.scopus.com/inward/record.url?scp=85042742145&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042742145&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-394447-4.20024-2
DO - 10.1016/B978-0-12-394447-4.20024-2
M3 - Chapter
AN - SCOPUS:85042742145
SN - 9780123947963
VL - 2
SP - 279
EP - 292
BT - Organizational Cell Biology
PB - Elsevier Inc.
ER -