Mechanisms and Functions of Mitochondrial Dynamics

K. Mihara, Hidenori Otera

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Mitochondrial morphology changes continuously through fusion, fission, and movement in response to different physiologic requirements of the cell. These highly dynamic behaviors are crucial for cell life and death, and are linked to development, apoptosis, and maintenance of cellular homeostasis; as well as to pathologies, such as neurologic and metabolic diseases. A large number of novel proteins involved in regulating mitochondrial dynamics have been discovered in the past decade. Large GTPase family proteins and their regulators control mitochondrial dynamics. Here, we summarize current knowledge about the molecular machineries regulating mitochondrial fusion/fission and the role of mitochondrial dynamics in cell pathophysiology.

Original languageEnglish
Title of host publicationOrganizational Cell Biology
PublisherElsevier Inc.
Pages279-292
Number of pages14
Volume2
ISBN (Electronic)9780123944474
ISBN (Print)9780123947963
DOIs
Publication statusPublished - Jan 1 2015

Fingerprint

Mitochondrial Dynamics
GTP Phosphohydrolases
Metabolic Diseases
Nervous System Diseases
Proteins
Homeostasis
Cell Death
Maintenance
Apoptosis
Pathology

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Mihara, K., & Otera, H. (2015). Mechanisms and Functions of Mitochondrial Dynamics. In Organizational Cell Biology (Vol. 2, pp. 279-292). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-394447-4.20024-2

Mechanisms and Functions of Mitochondrial Dynamics. / Mihara, K.; Otera, Hidenori.

Organizational Cell Biology. Vol. 2 Elsevier Inc., 2015. p. 279-292.

Research output: Chapter in Book/Report/Conference proceedingChapter

Mihara, K & Otera, H 2015, Mechanisms and Functions of Mitochondrial Dynamics. in Organizational Cell Biology. vol. 2, Elsevier Inc., pp. 279-292. https://doi.org/10.1016/B978-0-12-394447-4.20024-2
Mihara K, Otera H. Mechanisms and Functions of Mitochondrial Dynamics. In Organizational Cell Biology. Vol. 2. Elsevier Inc. 2015. p. 279-292 https://doi.org/10.1016/B978-0-12-394447-4.20024-2
Mihara, K. ; Otera, Hidenori. / Mechanisms and Functions of Mitochondrial Dynamics. Organizational Cell Biology. Vol. 2 Elsevier Inc., 2015. pp. 279-292
@inbook{4cf5c33e8c5f46c2a0092d2731ff9139,
title = "Mechanisms and Functions of Mitochondrial Dynamics",
abstract = "Mitochondrial morphology changes continuously through fusion, fission, and movement in response to different physiologic requirements of the cell. These highly dynamic behaviors are crucial for cell life and death, and are linked to development, apoptosis, and maintenance of cellular homeostasis; as well as to pathologies, such as neurologic and metabolic diseases. A large number of novel proteins involved in regulating mitochondrial dynamics have been discovered in the past decade. Large GTPase family proteins and their regulators control mitochondrial dynamics. Here, we summarize current knowledge about the molecular machineries regulating mitochondrial fusion/fission and the role of mitochondrial dynamics in cell pathophysiology.",
author = "K. Mihara and Hidenori Otera",
year = "2015",
month = "1",
day = "1",
doi = "10.1016/B978-0-12-394447-4.20024-2",
language = "English",
isbn = "9780123947963",
volume = "2",
pages = "279--292",
booktitle = "Organizational Cell Biology",
publisher = "Elsevier Inc.",
address = "United States",

}

TY - CHAP

T1 - Mechanisms and Functions of Mitochondrial Dynamics

AU - Mihara, K.

AU - Otera, Hidenori

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Mitochondrial morphology changes continuously through fusion, fission, and movement in response to different physiologic requirements of the cell. These highly dynamic behaviors are crucial for cell life and death, and are linked to development, apoptosis, and maintenance of cellular homeostasis; as well as to pathologies, such as neurologic and metabolic diseases. A large number of novel proteins involved in regulating mitochondrial dynamics have been discovered in the past decade. Large GTPase family proteins and their regulators control mitochondrial dynamics. Here, we summarize current knowledge about the molecular machineries regulating mitochondrial fusion/fission and the role of mitochondrial dynamics in cell pathophysiology.

AB - Mitochondrial morphology changes continuously through fusion, fission, and movement in response to different physiologic requirements of the cell. These highly dynamic behaviors are crucial for cell life and death, and are linked to development, apoptosis, and maintenance of cellular homeostasis; as well as to pathologies, such as neurologic and metabolic diseases. A large number of novel proteins involved in regulating mitochondrial dynamics have been discovered in the past decade. Large GTPase family proteins and their regulators control mitochondrial dynamics. Here, we summarize current knowledge about the molecular machineries regulating mitochondrial fusion/fission and the role of mitochondrial dynamics in cell pathophysiology.

UR - http://www.scopus.com/inward/record.url?scp=85042742145&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042742145&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-394447-4.20024-2

DO - 10.1016/B978-0-12-394447-4.20024-2

M3 - Chapter

SN - 9780123947963

VL - 2

SP - 279

EP - 292

BT - Organizational Cell Biology

PB - Elsevier Inc.

ER -