Mechanisms of aging in senescence-accelerated mice.

Todd A. Carter, Jennifer A. Greenhall, Shigeo Yoshida, Sebastian Fuchs, Robert Helton, Anand Swaroop, David J. Lockhart, Carrolee Barlow

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: Progressive neurological dysfunction is a key aspect of human aging. Because of underlying differences in the aging of mice and humans, useful mouse models have been difficult to obtain and study. We have used gene-expression analysis and polymorphism screening to study molecular senescence of the retina and hippocampus in two rare inbred mouse models of accelerated neurological senescence (SAMP8 and SAMP10) that closely mimic human neurological aging, and in a related normal strain (SAMR1) and an unrelated normal strain (C57BL/6J). RESULTS: The majority of age-related gene expression changes were strain-specific, with only a few common pathways found for normal and accelerated neurological aging. Polymorphism screening led to the identification of mutations that could have a direct impact on important disease processes, including a mutation in a fibroblast growth factor gene, Fgf1, and a mutation in and ectopic expression of the gene for the chemokine CCL19, which is involved in the inflammatory response. CONCLUSION: We show that combining the study of inbred mouse strains with interesting traits and gene-expression profiling can lead to the discovery of genes important for complex phenotypes. Furthermore, full-genome polymorphism detection, sequencing and gene-expression profiling of inbred mouse strains with interesting phenotypic differences may provide unique insights into the molecular genetics of late-manifesting complex diseases.

Original languageEnglish
JournalGenome biology
Volume6
Issue number6
Publication statusPublished - Jan 1 2005

Fingerprint

senescence
gene expression
senescence (aging)
Inbred Strains Mice
Gene Expression Profiling
mutation
Mutation
polymorphism
mice
Chemokine CCL19
Neurological Models
Gene Expression
genetic polymorphism
gene
Fibroblast Growth Factors
Genetic Association Studies
animal models
Retina
Molecular Biology
Hippocampus

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Cell Biology

Cite this

Carter, T. A., Greenhall, J. A., Yoshida, S., Fuchs, S., Helton, R., Swaroop, A., ... Barlow, C. (2005). Mechanisms of aging in senescence-accelerated mice. Genome biology, 6(6).

Mechanisms of aging in senescence-accelerated mice. / Carter, Todd A.; Greenhall, Jennifer A.; Yoshida, Shigeo; Fuchs, Sebastian; Helton, Robert; Swaroop, Anand; Lockhart, David J.; Barlow, Carrolee.

In: Genome biology, Vol. 6, No. 6, 01.01.2005.

Research output: Contribution to journalArticle

Carter, TA, Greenhall, JA, Yoshida, S, Fuchs, S, Helton, R, Swaroop, A, Lockhart, DJ & Barlow, C 2005, 'Mechanisms of aging in senescence-accelerated mice.', Genome biology, vol. 6, no. 6.
Carter TA, Greenhall JA, Yoshida S, Fuchs S, Helton R, Swaroop A et al. Mechanisms of aging in senescence-accelerated mice. Genome biology. 2005 Jan 1;6(6).
Carter, Todd A. ; Greenhall, Jennifer A. ; Yoshida, Shigeo ; Fuchs, Sebastian ; Helton, Robert ; Swaroop, Anand ; Lockhart, David J. ; Barlow, Carrolee. / Mechanisms of aging in senescence-accelerated mice. In: Genome biology. 2005 ; Vol. 6, No. 6.
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